Dorsal root compression produces myelinated axonal degeneration near the biomechanical thresholds for mechanical behavioral hypersensitivity

Increased sensitivity to mechanical stimuli produced by transient cervical nerve root compression is dependent on the severity of applied load. In addition, trauma in the nervous system induces local inflammation, Wallerian degeneration, and a host of other degenerative processes leading to axonal d...

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Bibliographic Details
Published in:Experimental neurology 2008-08, Vol.212 (2), p.482-489
Main Authors: Hubbard, Raymond D., Winkelstein, Beth A.
Format: Article
Language:English
Subjects:
Animals
Antigens, CD - metabolism
Antigens, Differentiation, Myelomonocytic - metabolism
Biological and medical sciences
Biomechanical Phenomena - methods
Cervical
Degeneration
Disease Models, Animal
Hyperalgesia - physiopathology
Inflammation
Injuries of the nervous system and the skull. Diseases due to physical agents
Macrophages - physiology
Male
Medical sciences
Nerve root
Neurofilament Proteins - metabolism
Neurology
Pain Threshold - physiology
Physical Stimulation - methods
Radiculopathy
Radiculopathy - complications
Radiculopathy - pathology
Rats
Spinal Nerve Roots - pathology
Spinal Nerve Roots - ultrastructure
Stress, Mechanical
Time Factors
Traumas. Diseases due to physical agents
Wallerian Degeneration - etiology
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