Early prediction of neurologic outcome after perinatal depression

Evaluation is presented of whether or not a detailed neuromotor examination at 3 months of age could predict later neurologic abnormalities among term infants with perinatal depression. In a prospective cohort, infants were neurologically evaluated at 3 and 12 months. Infants were scored from 0 to 5...

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Bibliographic Details
Published in:Pediatric neurology 1999-11, Vol.21 (5), p.788-793
Main Authors: Hajnal, Beatrice Latal, Sahebkar-Moghaddam, Farhad, Barnwell, Alison J, Barkovich, A.Jim, Ferriero, Donna M
Format: Article
Language:English
Subjects:
Age Factors
Biological and medical sciences
Delivery. Postpartum. Lactation
Disorders
Female
Gynecology. Andrology. Obstetrics
Humans
Infant
Male
Medical sciences
Nervous System Diseases - diagnosis
Neurologic Examination - methods
Neurologic Examination - statistics & numerical data
Prognosis
Prospective Studies
Psychomotor Disorders - diagnosis
Seizures
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Summary:Evaluation is presented of whether or not a detailed neuromotor examination at 3 months of age could predict later neurologic abnormalities among term infants with perinatal depression. In a prospective cohort, infants were neurologically evaluated at 3 and 12 months. Infants were scored from 0 to 5 according to a new neuromotor scoring system. The neuromotor score at 3 months (NMS-3) was compared with the NMS at 12 months (NMS-12). Seventy-four infants were enrolled in the study; nine were lost to follow-up, and five died before reaching 1 year. Sixty infants were examined (neurologic abnormalities = 52%, normal = 48% at 1 year). The NMS-3 correlated strongly with the NMS-12 and the results of the 12-month neurologic examination. All infants with a NMS-3 of 5 had neurologic abnormalities at 1 year. Infants with neonatal seizures had a significantly increased risk of developmental abnormalities at 1 year. Eighteen infants exhibited transient abnormalities. Using a simple scoring system, the results of the early neurologic examinations correlated strongly with outcome among term infants with perinatal depression. A subgroup of infants had transient abnormalities. These findings suggest that in term high-risk infants, the 1-year neurologic outcome can be predicted at 3 months of age using these parameters.
ISSN:0887-8994
1873-5150
DOI:10.1016/S0887-8994(99)00101-0