Regulatory immune cells in kidney disease

Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these immune cells (regulatory T lymphocytes and alternately-activated or regulatory macrophages) are potent modulators of tissue injury and repai...

Full description

Saved in:
Bibliographic Details
Published in:American journal of physiology. Renal physiology 2008-08, Vol.295 (2), p.F335-F342
Main Authors: Lee, V W S, Wang, Y M, Wang, Y P, Zheng, D, Polhill, T, Cao, Q, Wu, H, Alexander, I E, Alexander, S I, Harris, D C H
Format: Article
Language:English
Subjects:
Animals
Dendritic Cells - pathology
Dendritic Cells - physiology
Humans
Immunology
Kidney diseases
Kidney Diseases - pathology
Kidney Diseases - physiopathology
Lymphocyte receptors
Macrophages - pathology
Macrophages - physiology
Mast Cells - pathology
Mast Cells - physiology
Nephrology
Studies
T cell receptors
T-Lymphocytes, Regulatory - pathology
T-Lymphocytes, Regulatory - physiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lymphocytes and macrophages act as effector immune cells in the initiation and progression of renal injury. Recent data have shown that subpopulations of these immune cells (regulatory T lymphocytes and alternately-activated or regulatory macrophages) are potent modulators of tissue injury and repair in renal disease. Recent animal studies examining the therapeutic effect of these cells raise the exciting possibility that strategies targeting these cell types may be effective in treating and preventing kidney disease in humans. This review will describe their biological role in experimental kidney disease and therapeutic potential in clinical nephrology.
ISSN:1931-857X
1522-1466
DOI:10.1152/ajprenal.00077.2008