Cardiovascular and renal effects of central administration of a mineralocorticoid receptor antagonist in conscious female rats

In a previous study we showed that in normotensive male rats brain mineralocorticoid receptor blockade induced a long lasting decrease in blood pressure associated with increased urinary excretion of water and electrolytes. Here, we report the effect of intracerebroventricular injection of a mineral...

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Bibliographic Details
Published in:European journal of pharmacology 1999-12, Vol.385 (2), p.199-202
Main Authors: Rahmouni, Kamal, Barthelmebs, Mariette, Grima, Michèle, Imbs, Jean Louis, De Jong, Wybren
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blood pressure
Blood Pressure - drug effects
Brain
Cardiovascular Physiological Phenomena - drug effects
Chlorides - urine
Consciousness
Female
Female rat
Fundamental and applied biological sciences. Psychology
Heart Rate - drug effects
Hemodynamics. Rheology
Injections, Intraventricular
Kidney - drug effects
Kidney - physiology
Male
Mineralocorticoid receptor
Mineralocorticoid Receptor Antagonists - pharmacology
Potassium - urine
Rats
Rats, Wistar
Renal function
RU28318
Sodium - urine
Spironolactone - analogs & derivatives
Spironolactone - pharmacology
Steroid hormones. Cholecalciferol derivatives
Systole
Urination - drug effects
Vertebrates: cardiovascular system
Vertebrates: endocrinology
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Summary:In a previous study we showed that in normotensive male rats brain mineralocorticoid receptor blockade induced a long lasting decrease in blood pressure associated with increased urinary excretion of water and electrolytes. Here, we report the effect of intracerebroventricular injection of a mineralocorticoid receptor antagonist (RU28318; 3,3-oxo-7 propyl-17-hydroxy-androstan-4-en-17yl-propionic acid lactone) on cardiovascular and renal function in female rats. Compared with male rats, females are less sensitive to brain mineralocorticoid receptor blockade. Administration of RU28318 (10 ng, 100 ng) caused a significant decrease in systolic blood pressure (10–12.5%) only at 8 h after injection. An increased urinary excretion of water (about 160%) and electrolytes (about 175%) during the first 8 h after the injection was observed in the 100 ng RU28318 treated group. Heart rate, food intake and water consumption were not affected at either dose. In conclusion, in conscious female rats, brain mineralocorticoid receptors participate in blood pressure and renal function control.
ISSN:0014-2999
1879-0712
DOI:10.1016/S0014-2999(99)00705-0