Chlorine Dioxide and Chlorhexidine Mouthrinses Compared in a 3‐Day Plaque Accumulation Model

• Published in: Journal of periodontology (1970) 2008-08, Vol.79 (8), p.1395-1400
• Main Authors: Paraskevas, Spiros, Rosema, Nanning A.M., Versteeg, Paula, Van der Velden, Ubele, Van der Weijden, G.A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Anti-Infective Agents, Local - therapeutic use; Biological and medical sciences; Chlorhexidine; Chlorhexidine - therapeutic use; Chlorine Compounds - therapeutic use; chlorine dioxide; clinical trial; dental plaque; Dental Plaque - prevention & control; Dental Plaque Index; Dentistry; Facial bones, jaws, teeth, parodontium: diseases, semeiology; Female; Humans; Male; Medical sciences; Middle Aged; Mouthwashes - therapeutic use; Non tumoral diseases; Otorhinolaryngology. Stomatology; Oxides - therapeutic use; Patient Satisfaction; Single-Blind Method; Taste - drug effects; Treatment Outcome
• ISSN: 0022-3492; 1943-3670
• DOI: 10.1902/jop.2008.070630

Background: The aim of this study was to investigate the inhibiting effect of a chlorine dioxide mouthrinse as opposed to a mouthrinse containing chlorhexidine (0.20%) during 3 days of plaque accumulation. Methods: At baseline, all participants (N = 77) received a professional prophylaxis and were randomly assigned to the test (chlorine dioxide) or (positive) control (chlorhexidine) group. On the following 3 days, both groups rinsed twice daily for 1 minute with 10 ml test or control solution. At the end of the experimental period, plaque was assessed, and the panelists filled out a questionnaire. Results: Chlorhexidine inhibited plaque growth significantly more than the mouthrinse containing chlorine dioxide (plaque index = 1.39 versus 1.96, respectively; P