Serum S100B but not NSE Levels are Increased in Morbidly Obese Individuals Affected by Obstructive Sleep Apnea–Hypopnea Syndrome

Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is considered a comorbidity associated with morbid obesity, mainly because of the large neck circumference. Depending on its severity, OSAHS can interfere in many homeostasis systems, for example, the central nervous system (CNS). Neuron-s...

Full description

Saved in:
Bibliographic Details
Published in:Obesity surgery 2008-08, Vol.18 (8), p.993-999
Main Authors: da Silva, Leandro Giacometti, Mottin, Cláudio Corá, Souza, Diogo Onofre, Portela, Luiz Valmor, Braga, Carla Winei, Vargas, Carolina Boeira, Padoin, Alexandre Vontobel, Martinez, Denis, Dias, Renato Dutra
Format: Article
Language:English
Subjects:
Adult
Biomarkers
Biomarkers - blood
Body Mass Index
Brain
Cohort Studies
Diagnostic tests
Female
Humans
Injuries
Male
Medicine
Medicine & Public Health
Middle Aged
Nerve Growth Factors - blood
Obesity
Obesity, Morbid - blood
Obesity, Morbid - complications
Phosphopyruvate Hydratase - blood
Polysomnography
Research Article
S100 Calcium Binding Protein beta Subunit
S100 Proteins - blood
Sleep - physiology
Sleep Apnea, Obstructive - blood
Sleep Apnea, Obstructive - complications
Sleep disorders
Surgery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Obstructive sleep apnea–hypopnea syndrome (OSAHS) is considered a comorbidity associated with morbid obesity, mainly because of the large neck circumference. Depending on its severity, OSAHS can interfere in many homeostasis systems, for example, the central nervous system (CNS). Neuron-specific enolase (NSE) and S100B protein derived from astrocytes are considered sensitive biochemical markers of cerebral injury. We evaluated serum S100B and NSE levels in this study with the aim of detecting possible cerebral injury as a consequence of OSAHS. Methods This was a transverse study with data from 25 morbidly obese patients with OSAHS. Blood samples were collected before and after polysomnography (PSG) to determine S100B and NSE protein levels. We also analyzed data evaluating depression and excessive daytime sleepiness. Results S100B levels were higher after [0.029 (0.010–0.199) mg/l] compared to before [0.010 (0.010–0.025) mg/l] on PSG ( P  = 0.002). S100B levels were expressed as means and IQ25–IQ75. NSE levels did not show significant differences before and after PSG. Conclusion Our study shows a significant increase in S100B level after PSG compared to before. This suggests that there is a CNS astrocyte reaction because of possible cerebral hypoxemia in morbidly obese patients with OSAHS.
ISSN:0960-8923
1708-0428
DOI:10.1007/s11695-007-9386-6