Protein C, protein S and antithrombin III deficiencies in retinal vein occlusion

• Published in: Acta ophthalmologica Scandinavica 1999-12, Vol.77 (6), p.628-630
• Main Authors: Tekeli, Oya, Gürsel, Emin, Buyurgan, Haluk
• Format: Article
• Language: English
• Subjects: Biomarkers - blood; Female; Fluorescein Angiography; Fundus Oculi; Humans; Male; Middle Aged; Protein C - metabolism; Protein C Deficiency - blood; Protein C Deficiency - complications; Protein S - metabolism; Protein S Deficiency - blood; Protein S Deficiency - complications; Retinal Vein Occlusion - blood; Retinal Vein Occlusion - diagnosis; Retinal Vein Occlusion - etiology; Retrospective Studies; Risk Factors
• ISSN: 1395-3907; 1600-0420
• DOI: 10.1034/j.1600-0420.1999.770604.x

The role of decreased levels of protein C, protein S and antithrombin III were investigated in patients with branch and central retinal vein occlusion. Forty-five patients with retinal vein occlusion and 20 healthy subjects as a control group was studied. Fourteen patients (31%) had central retinal vein occlusion and 31 (69%) had branch retinal vein occlusion. The concentrations of protein C, protein S and antithrombin III were measured. Plasma levels of protein C, protein S and antithrombin III were not reduced in the control group. Six of the 14 central retinal vein occlusion cases and 3 of the 31 retinal branch vein occlusion cases had decreased levels of protein C. One of the 14 central retinal vein occlusion cases and 1 of the 31 retinal branch vein occlusion cases had decreased levels of protein S. Antithrombin III was reduced in 1 patient of the 31 retinal branch vein occlusions. We found statistically significant differences for number of cases with protein C deficiency between the central retinal vein occlusion cases and the branch retinal vein occlusion cases (p