Gallstones and Clonorchis sinensis infection: A hospital-based case-control study in Korea

Background and Aim:  A high prevalence of intrahepatic stones in some areas of East Asia has been believed to be related with Clonorchis sinensis infection. The authors conducted a hospital‐based case–control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the develo...

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Published in:Journal of gastroenterology and hepatology 2008-08, Vol.23 (8pt2), p.e399-e404
Main Authors: Choi, Dongil, Lim, Jae Hoon, Lee, Kyu Taek, Lee, Jong Kyun, Choi, Seong Ho, Heo, Jin Seok, Choi, Dong Wook, Jang, Kee-Taek, Lee, Nam Yong, Kim, Seonwoo, Hong, Sung-Tae
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Case-Control Studies
case-control study
Clonorchiasis - complications
Clonorchiasis - diagnosis
Clonorchis sinensis
Female
gallstone
Gallstones - diagnosis
Gallstones - etiology
Humans
Korea
Male
Middle Aged
risk factor
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Summary:Background and Aim:  A high prevalence of intrahepatic stones in some areas of East Asia has been believed to be related with Clonorchis sinensis infection. The authors conducted a hospital‐based case–control study to evaluate the role of Clonorchis sinensis infection as a risk factor for the development of gallstones in Korea. Methods:  The cases of 138 patients with gallstones (intrahepatic 44, gallbladder 67, and extrahepatic 27) and matched controls underwent microscopy for C. sinensis, serological tests for C. sinensis using enzyme‐linked immunosorbent assay, radiological examinations, and interviews concerning the history of eating raw freshwater fish. We assessed a relationship of three types of gallstones and variables regarding C. sinensis by using univariate and multivariate statistical analyses. Results:  Univariate statistical analyses showed that radiological evidence of C. sinensis and recent history of eating raw freshwater fish were related to an increased risk of intrahepatic stones (P = 0.0002 and 0.0039, respectively). According to multivariate statistical analyses, radiological evidence of C. sinensis was the only risk factor for intrahepatic stones (odds ratio = 7.835; 95% confidence interval = 1.671–36.724). Any evidence regarding C. sinensis was not related to an increased risk of either gallbladder or extrahepatic stones. Conclusion:  Radiological evidence of C. sinensis was significantly associated with intrahepatic stones.
ISSN:0815-9319
1440-1746
DOI:10.1111/j.1440-1746.2007.05242.x