Racial Differences in Blood Pressure Response to Angiotensin-Converting Enzyme Inhibitors in Children: A Meta-Analysis

Angiotensin‐converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.1 ACE inhibitors alter the balance between the vasoconstrictive, salt‐retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilatory and natriuretic properties of bradykinin; t...

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Bibliographic Details
Published in:Clinical pharmacology and therapeutics 2008-09, Vol.84 (3), p.315-319
Main Authors: Li, JS, Baker‐Smith, CM, Smith, PB, Hasselblad, V, Murphy, MD, Califf, RM, Benjamin, DK
Format: Article
Language:English
Subjects:
Adolescent
African Continental Ancestry Group
Angiotensin-Converting Enzyme Inhibitors - pharmacology
Angiotensin-Converting Enzyme Inhibitors - therapeutic use
Antihypertensive Agents - pharmacology
Antihypertensive Agents - therapeutic use
Biological and medical sciences
Blood Pressure - drug effects
Child
European Continental Ancestry Group
Female
Humans
Hypertension - drug therapy
Male
Medical sciences
Pharmacology. Drug treatments
Randomized Controlled Trials as Topic
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Summary:Angiotensin‐converting enzyme (ACE) inhibitors are frequently used to treat hypertension in children.1 ACE inhibitors alter the balance between the vasoconstrictive, salt‐retentive, and cardiac hypertrophic properties of angiotensin II and the vasodilatory and natriuretic properties of bradykinin; they also alter the metabolism of other vasoactive substances.2 Through these mechanisms, ACE inhibitors decrease systemic vascular resistance and promote natriuresis without increasing heart rate. This study evaluated the results of six trials of ACE inhibitors in children, using meta‐analytic techniques to estimate the effect of race on blood pressure response. Clinical Pharmacology & Therapeutics (2008); 84, 3, 315–319 doi:10.1038/clpt.2008.113
ISSN:0009-9236
1532-6535
DOI:10.1038/clpt.2008.113