In-Hospital Stroke Treated With Intravenous Tissue Plasminogen Activator

In-hospital strokes (IHSs) are potential candidates for thrombolysis. We analyzed the treatment procedures, safety, and efficacy of intravenous tissue plasminogen activator (IV-tPA) in IHSs compared with out-of-hospital strokes (OHSs). This study was based on a multicenter prospective registry of pa...

Full description

Saved in:
Bibliographic Details
Published in:Stroke (1970) 2008-09, Vol.39 (9), p.2614-2616
Main Authors: MASJUAN, Jaime, SIMAL, Patricia, FUENTES, Blanca, EGIDO, José Antonio, DFAZ-OTERO, Fernando, GIL-NUNEZ, Antonio, NOVILLO-LOPEZ, Maria Elena, DIEZ-TEJEDOR, Exuperio, DE LECINANA, Maria Alonso
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Atrial Fibrillation - epidemiology
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Diabetes Mellitus - epidemiology
Early Diagnosis
Emergency Medical Services - statistics & numerical data
Female
Fibrinolytic Agents - administration & dosage
Heart Failure - epidemiology
Hospitalization - statistics & numerical data
Humans
Injections, Intravenous
Male
Medical sciences
Middle Aged
Neurology
Pharmacology. Drug treatments
Prospective Studies
Quality of Health Care - trends
Registries
Stroke - drug therapy
Stroke - nursing
Thrombolytic Therapy - methods
Thrombolytic Therapy - statistics & numerical data
Time Factors
Tissue Plasminogen Activator - administration & dosage
Tomography, X-Ray Computed
Treatment Outcome
Vascular diseases and vascular malformations of the nervous system
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In-hospital strokes (IHSs) are potential candidates for thrombolysis. We analyzed the treatment procedures, safety, and efficacy of intravenous tissue plasminogen activator (IV-tPA) in IHSs compared with out-of-hospital strokes (OHSs). This study was based on a multicenter prospective registry of patients treated with IV-tPA divided into IHSs and OHSs. We recorded intrahospital delays and stroke outcomes. Among 367 patients treated with IV-tPA, 30 were IHSs. Baseline characteristics were similar except for a greater proportion of diabetes (36.7% vs 17.5%, P=0.01), cardiac failure (16.7% vs 5.3%, P=0.014), and atrial fibrillation (33.3% vs 17.5%, P=0.034) in IHSs than OHSs. In-hospital delays were significantly longer in IHSs for door-to-computed tomography time (39.5+/-18.7 vs 22.6+/-19.7 minutes, P
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.107.512848