The role of the epidermal growth factor receptor in microbial infections of the gastrointestinal tract

The epidermal growth factor receptor (EGFr) is a transmembrane glycoprotein with an intrinsic tyrosine kinase. Ligand-binding to the EGFr activates cell signaling, phosphorylates protein kinases, and rearranges cytoskeletal proteins – responses that resemble those induced by microbial attachment to...

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Bibliographic Details
Published in:Microbes and Infection 1999-11, Vol.1 (13), p.1139-1144
Main Authors: Buret, Andre, Gall, D.Grant, Olson, Merle E., Hardin, James A.
Format: Article
Language:English
Subjects:
Animals
Bacteria - metabolism
Bacteria - pathogenicity
Bacterial Infections - metabolism
Bacterial Infections - microbiology
Biological and medical sciences
epidermal growth factor
epidermal growth factor receptors
epithelial
Eukaryota - metabolism
Eukaryota - pathogenicity
gastrointestinal
Gastrointestinal Diseases - metabolism
Gastrointestinal Diseases - microbiology
Gastrointestinal Diseases - parasitology
Gastrointestinal Diseases - virology
General aspects
Human infectious diseases. Experimental studies and models
Humans
infection
Infectious diseases
Medical sciences
Protozoan Infections - metabolism
Protozoan Infections - parasitology
Receptor, Epidermal Growth Factor - metabolism
Virus Diseases - metabolism
Virus Diseases - virology
Viruses - metabolism
Viruses - pathogenicity
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Summary:The epidermal growth factor receptor (EGFr) is a transmembrane glycoprotein with an intrinsic tyrosine kinase. Ligand-binding to the EGFr activates cell signaling, phosphorylates protein kinases, and rearranges cytoskeletal proteins – responses that resemble those induced by microbial attachment to cell surfaces, a process known to be mediated by host cell receptors in a number of cases. This article critically reviews the possible role played by the EGFr in microbial colonization, and discusses how modulation of the EGF-EGFr axis may affect infection of the gastrointestinal tract.
ISSN:1286-4579
1769-714X
DOI:10.1016/S1286-4579(99)00201-4