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Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide
The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper m...
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| Published in: | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy Molecular and biomolecular spectroscopy, 2008-11, Vol.71 (1), p.73-79 |
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| cites | cdi_FETCH-LOGICAL-c351t-58f268f82f25e47a3fddb5d1c525de14bc0f28b8c2857d9f54dbb6cc0b322fa33 |
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| container_title | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy |
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| creator | Hassanien, M.M. Gabr, I.M. Abdel-Rhman, M.H. El-Asmy, A.A. |
| description | The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper metal is easily oxidized in aqueous-ethanol solution of HEPTS giving [Cu
2(EPTS)(H
2O)
3(OH)
3]EtOH. Different complexes for the same anion were synthesized by controlling the heating time. Characterization by elemental, thermal, magnetic and spectral (electronic, IR, mass and ESR) studies showed the formation of mono-, di-, tri- and tetra nuclear complexes. The room temperature solid state ESR spectra of the complexes show an axial spectrum with
d
x
2
−
y
2
ground state, suggesting distorted tetragonal geometry around Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in the complexes were calculated. HEPTS and its Cu(II) complexes showed high activity against gram negative bacteria; [Cu
3(EPTS)
2(EtOH)
2Br
4] has more activity. |
| doi_str_mv | 10.1016/j.saa.2007.11.009 |
| format | article |
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2(EPTS)(H
2O)
3(OH)
3]EtOH. Different complexes for the same anion were synthesized by controlling the heating time. Characterization by elemental, thermal, magnetic and spectral (electronic, IR, mass and ESR) studies showed the formation of mono-, di-, tri- and tetra nuclear complexes. The room temperature solid state ESR spectra of the complexes show an axial spectrum with
d
x
2
−
y
2
ground state, suggesting distorted tetragonal geometry around Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in the complexes were calculated. HEPTS and its Cu(II) complexes showed high activity against gram negative bacteria; [Cu
3(EPTS)
2(EtOH)
2Br
4] has more activity.</description><identifier>ISSN: 1386-1425</identifier><identifier>DOI: 10.1016/j.saa.2007.11.009</identifier><identifier>PMID: 18164649</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Anti-Infective Agents - chemistry ; Biological activity ; Chemistry, Pharmaceutical - methods ; Copper - chemistry ; Copper complexes ; Drug Design ; Electron Spin Resonance Spectroscopy - methods ; Electronic spectra ; ESR ; Infrared ; Ligands ; Magnetic Resonance Spectroscopy ; Magnetics ; Metals - chemistry ; Models, Chemical ; Molecular Structure ; Semicarbazides - analysis ; Semicarbazides - chemistry ; Spectrophotometry, Infrared - methods ; Spectrophotometry, Ultraviolet - methods ; Temperature ; Thiosemicarbazide</subject><ispartof>Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2008-11, Vol.71 (1), p.73-79</ispartof><rights>2007 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c351t-58f268f82f25e47a3fddb5d1c525de14bc0f28b8c2857d9f54dbb6cc0b322fa33</citedby><cites>FETCH-LOGICAL-c351t-58f268f82f25e47a3fddb5d1c525de14bc0f28b8c2857d9f54dbb6cc0b322fa33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18164649$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassanien, M.M.</creatorcontrib><creatorcontrib>Gabr, I.M.</creatorcontrib><creatorcontrib>Abdel-Rhman, M.H.</creatorcontrib><creatorcontrib>El-Asmy, A.A.</creatorcontrib><title>Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide</title><title>Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy</title><addtitle>Spectrochim Acta A Mol Biomol Spectrosc</addtitle><description>The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper metal is easily oxidized in aqueous-ethanol solution of HEPTS giving [Cu
2(EPTS)(H
2O)
3(OH)
3]EtOH. Different complexes for the same anion were synthesized by controlling the heating time. Characterization by elemental, thermal, magnetic and spectral (electronic, IR, mass and ESR) studies showed the formation of mono-, di-, tri- and tetra nuclear complexes. The room temperature solid state ESR spectra of the complexes show an axial spectrum with
d
x
2
−
y
2
ground state, suggesting distorted tetragonal geometry around Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in the complexes were calculated. HEPTS and its Cu(II) complexes showed high activity against gram negative bacteria; [Cu
3(EPTS)
2(EtOH)
2Br
4] has more activity.</description><subject>Anti-Infective Agents - chemistry</subject><subject>Biological activity</subject><subject>Chemistry, Pharmaceutical - methods</subject><subject>Copper - chemistry</subject><subject>Copper complexes</subject><subject>Drug Design</subject><subject>Electron Spin Resonance Spectroscopy - methods</subject><subject>Electronic spectra</subject><subject>ESR</subject><subject>Infrared</subject><subject>Ligands</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Magnetics</subject><subject>Metals - chemistry</subject><subject>Models, Chemical</subject><subject>Molecular Structure</subject><subject>Semicarbazides - analysis</subject><subject>Semicarbazides - chemistry</subject><subject>Spectrophotometry, Infrared - methods</subject><subject>Spectrophotometry, Ultraviolet - methods</subject><subject>Temperature</subject><subject>Thiosemicarbazide</subject><issn>1386-1425</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kD2P1DAURV2A2GXhB9CgVAgKZ_2cOOOICq34klbaYpfacuxnxiMnDrazIhT8djLMSHRUtzn3SvcQ8gpYDQy660Odta45Y7saoGasf0IuoZEdhZaLC_I85wNjDCRnz8gFSOjaru0vye_7dSp7zD5XerJVLmkxZUk6VH56xFz8d118nKroqjFOkf6l5hjWaTEBdapMnGc8xjgH_In5SLYUy34NFOjbeU3e-olyuoZ3Vdn7mHH0RqdB__IWX5CnToeML895Rb59-vhw84Xe3n3-evPhlppGQKFCOt5JJ7njAtudbpy1g7BgBBcWoR0Mc1wO0nApdrZ3orXD0BnDhoZzp5vmirw57c4p_li2X2r02WAIesK4ZNX1rex6LjcQTqBJMeeETs3JjzqtCpg6ilYHtYlWR9EKQG2it87r8_gyjGj_Nc6WN-D9CcDt4qPHpLLxOBm0PqEpykb_n_k_HGqTDg</recordid><startdate>20081101</startdate><enddate>20081101</enddate><creator>Hassanien, M.M.</creator><creator>Gabr, I.M.</creator><creator>Abdel-Rhman, M.H.</creator><creator>El-Asmy, A.A.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081101</creationdate><title>Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide</title><author>Hassanien, M.M. ; Gabr, I.M. ; Abdel-Rhman, M.H. ; El-Asmy, A.A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c351t-58f268f82f25e47a3fddb5d1c525de14bc0f28b8c2857d9f54dbb6cc0b322fa33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Anti-Infective Agents - chemistry</topic><topic>Biological activity</topic><topic>Chemistry, Pharmaceutical - methods</topic><topic>Copper - chemistry</topic><topic>Copper complexes</topic><topic>Drug Design</topic><topic>Electron Spin Resonance Spectroscopy - methods</topic><topic>Electronic spectra</topic><topic>ESR</topic><topic>Infrared</topic><topic>Ligands</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Magnetics</topic><topic>Metals - chemistry</topic><topic>Models, Chemical</topic><topic>Molecular Structure</topic><topic>Semicarbazides - analysis</topic><topic>Semicarbazides - chemistry</topic><topic>Spectrophotometry, Infrared - methods</topic><topic>Spectrophotometry, Ultraviolet - methods</topic><topic>Temperature</topic><topic>Thiosemicarbazide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassanien, M.M.</creatorcontrib><creatorcontrib>Gabr, I.M.</creatorcontrib><creatorcontrib>Abdel-Rhman, M.H.</creatorcontrib><creatorcontrib>El-Asmy, A.A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassanien, M.M.</au><au>Gabr, I.M.</au><au>Abdel-Rhman, M.H.</au><au>El-Asmy, A.A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide</atitle><jtitle>Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy</jtitle><addtitle>Spectrochim Acta A Mol Biomol Spectrosc</addtitle><date>2008-11-01</date><risdate>2008</risdate><volume>71</volume><issue>1</issue><spage>73</spage><epage>79</epage><pages>73-79</pages><issn>1386-1425</issn><abstract>The reaction between 2-hydrazinopyridine and ethylisothiocyanate produced 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide (HEPTS). Its reaction with copper fluoride, chloride, bromide, acetate, nitrate, perchlorate, sulfate, carbonate, hydroxide and copper metal produced 15 Cu(II) complexes. The copper metal is easily oxidized in aqueous-ethanol solution of HEPTS giving [Cu
2(EPTS)(H
2O)
3(OH)
3]EtOH. Different complexes for the same anion were synthesized by controlling the heating time. Characterization by elemental, thermal, magnetic and spectral (electronic, IR, mass and ESR) studies showed the formation of mono-, di-, tri- and tetra nuclear complexes. The room temperature solid state ESR spectra of the complexes show an axial spectrum with
d
x
2
−
y
2
ground state, suggesting distorted tetragonal geometry around Cu(II) center. The kinetic and thermodynamic parameters for the different decomposition steps in the complexes were calculated. HEPTS and its Cu(II) complexes showed high activity against gram negative bacteria; [Cu
3(EPTS)
2(EtOH)
2Br
4] has more activity.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>18164649</pmid><doi>10.1016/j.saa.2007.11.009</doi><tpages>7</tpages></addata></record> |
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| ispartof | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2008-11, Vol.71 (1), p.73-79 |
| issn | 1386-1425 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Anti-Infective Agents - chemistry Biological activity Chemistry, Pharmaceutical - methods Copper - chemistry Copper complexes Drug Design Electron Spin Resonance Spectroscopy - methods Electronic spectra ESR Infrared Ligands Magnetic Resonance Spectroscopy Magnetics Metals - chemistry Models, Chemical Molecular Structure Semicarbazides - analysis Semicarbazides - chemistry Spectrophotometry, Infrared - methods Spectrophotometry, Ultraviolet - methods Temperature Thiosemicarbazide |
| title | Synthesis and structural investigation of mono- and polynuclear copper complexes of 4-ethyl-1-(pyridin-2-yl) thiosemicarbazide |
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