Facilitation of sympathetic neurotransmission contributes to angiotensin regulation of body weight

Previous studies demonstrated that angiotensin II (AnglI) decreases body weight. The purpose of this study was to determine if AngII-reductions in body weight result from stimulation of sympathetic neurotransmission to interscapular brown adipose tissue (ISBAT). Following 7 days of chronic AngII inf...

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Bibliographic Details
Published in:Journal of Neural Transmission 1999-01, Vol.106 (7-8), p.631-644
Main Authors: ENGLISH, V, CASSIS, L
Format: Article
Language:English
Subjects:
Adipose Tissue, Brown - drug effects
Adipose Tissue, Brown - metabolism
Adrenergic Fibers - drug effects
Adrenergic Fibers - metabolism
Angiotensin II - pharmacology
Animals
Biological and medical sciences
Blood Pressure - drug effects
Blood Pressure - physiology
Body Weight - drug effects
Body Weight - physiology
Drinking - drug effects
Drinking - physiology
Eating - drug effects
Eating - physiology
Endocrine kidney. Renin-angiotensin-aldosterone system
Fundamental and applied biological sciences. Psychology
Male
Norepinephrine - metabolism
Rats
Rats, Sprague-Dawley
Synaptic Transmission - drug effects
Vasoconstrictor Agents - pharmacology
Vertebrates: endocrinology
Citations: Items that cite this one
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Summary:Previous studies demonstrated that angiotensin II (AnglI) decreases body weight. The purpose of this study was to determine if AngII-reductions in body weight result from stimulation of sympathetic neurotransmission to interscapular brown adipose tissue (ISBAT). Following 7 days of chronic AngII infusion (350ng/kg/min), body weight decreased compared to controls. Using superfused ISBAT tissue slices preloaded with [3H]norepinephrine (NE), evoked [3H]overflow was greater in ISBAT slices from AngII-infused rats compared to controls. When AngII was included in the buffer, evoked [3H]overflow increased in a concentration-dependent manner in ISBAT slices from AngII-infused and control rats. The EC50 for the presynaptic effect of AngII was shifted to the left in ISBAT slices from AnglI-infused rats compared to controls; however, the maximal response to AngII was decreased. These results demonstrate that chronic AngII infusion enhances evoked release of NE from ISBAT sympathetic nerve terminals. Moreover, responsiveness to the presynaptic effect of AngII was altered following chronic AngII infusion. Increased sympathetic neurotransmission to ISBAT may contribute to AnglI-regulation of body weight.
ISSN:0300-9564
1435-1463
DOI:10.1007/s007020050185