A comparison of anaesthetic tensions in arterial blood and oxygenator exhaust gas during cardiopulmonary bypass

This study evaluates the usefulness of the analysis of gas sampled from the exhaust port of a membrane oxygenator in the estimation of anaesthetic tension in arterial blood. Sixty‐seven arterial blood samples were drawn from patients undergoing hypothermic cardiopulmonary bypass with anaesthesia mai...

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Bibliographic Details
Published in:Anaesthesia 1999-05, Vol.54 (5), p.434-436
Main Authors: Lockwood, G. G., Sapsed‐Byrne, S. M., Adams, S.
Format: Article
Language:English
Subjects:
Anaesthetics, inhalation
desflurane, isoflurane
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Inhalation - blood
Anesthetics, Inhalation - pharmacokinetics
Biological and medical sciences
Carbon Dioxide - blood
Cardiopulmonary Bypass
Desflurane
Evaluation Studies as Topic
Humans
Isoflurane - analogs & derivatives
Isoflurane - blood
Isoflurane - pharmacokinetics
Medical sciences
Monitoring, Intraoperative - methods
Monitoring
intra‐operative
Oxygen - blood
Oxygenators, Membrane
Partial Pressure
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Summary:This study evaluates the usefulness of the analysis of gas sampled from the exhaust port of a membrane oxygenator in the estimation of anaesthetic tension in arterial blood. Sixty‐seven arterial blood samples were drawn from patients undergoing hypothermic cardiopulmonary bypass with anaesthesia maintained by either isoflurane or desflurane. Anaesthetic tensions in the oxygenator exhaust gas were measured using an infrared analyser and in arterial blood using a two‐stage headspace technique with a gas chromatograph. Both measurement systems were calibrated with the same standard gas mixtures. There was no difference in anaesthetic tension measured in arterial blood and gas leaving the oxygenator exhaust (isoflurane: n = 29, range: 0.3–0.8%, 95% limits of agreement: − 0.08% to 0.09%; desflurane: n = 38, range: 1.5–5.4%; 95% limits of agreement − 0.65% to 0.58%). We conclude that anaesthetic tensions in arterial blood can be accurately monitored by analysis of the gas emerging from the exhaust port of a membrane oxygenator.
ISSN:0003-2409
1365-2044
DOI:10.1046/j.1365-2044.1999.00847.x