Highlights of the 2007 Progeria Research Foundation Scientific Workshop: Progress in Translational Science

The first PRF Scientific Workshop in 2001 helped to identify nuclear blebbing as an important phenotypic marker of progeria cells (noted by Anthony Weiss; University of Sydney, Australia), and to recognize a translocation on chromosome 1 in the cells cultured from a progeria patient (W. Ted Brown, N...

Full description

Saved in:
Bibliographic Details
Published in:The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2008-08, Vol.63 (8), p.777-787
Main Authors: Gordon, Leslie B., Harling-Berg, Christine J., Rothman, Frank G.
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Child
Children & youth
Clinical trials
Clinical Trials as Topic
Congresses as Topic
Developmental disabilities
DNA Damage - physiology
Genetic disorders
Humans
Lamin Type A - genetics
Laminin - physiology
Medical research
Medical treatment
Progeria - drug therapy
Progeria - genetics
Progeria - physiopathology
Research Design
Stem Cells - physiology
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The first PRF Scientific Workshop in 2001 helped to identify nuclear blebbing as an important phenotypic marker of progeria cells (noted by Anthony Weiss; University of Sydney, Australia), and to recognize a translocation on chromosome 1 in the cells cultured from a progeria patient (W. Ted Brown, New York State Institute for Basic Research in Developmental Disabilities), pointing geneticists in the direction of the gene mutation for progeria (3). The essence of translational research was represented in the presentations, which brought forth the most important issues in progeria today-the effects of progerin and lamins and their binding partners on the functioning of cells, systems, mouse models, and humans; the connection between progeria, aging, and cardiovascular disease in the general population; careful analysis of FTI effects on progeria at all levels (summarized in Table 1); and strategies for future disease treatments and cure.
ISSN:1079-5006
1758-535X
DOI:10.1093/gerona/63.8.777