Antisense oligonucleotide treatment reveals a physiologically relevant role for adrenomedullin gene products in sodium intake

Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose-dependently inhibits sodium appetite. AM antisense oligonucleotide treatment signi...

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Bibliographic Details
Published in:Brain research 1999-02, Vol.818 (1), p.164-167
Main Authors: Samson, Willis K, Bode, Ann M, Murphy, Tonya C, Resch, Zachary T
Format: Article
Language:English
Subjects:
Adrenomedullin
Animals
Antihypertensive Agents - pharmacology
Antisense
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
Homeostasis - drug effects
Male
Metabolisms and neurohumoral controls
Oligonucleotides, Antisense - pharmacology
Peptides - genetics
Rats
Rats, Sprague-Dawley
Salt appetite
Sodium - pharmacology
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Water and mineral metabolism. Osmoregulation. Acidobasic balance
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Summary:Adrenomedullin (AM), a potent hypotensive peptide, is produced in numerous tissues including adrenal gland, kidney, brain and pituitary gland, where it acts to modify sodium homeostasis. Central AM administration dose-dependently inhibits sodium appetite. AM antisense oligonucleotide treatment significantly lowered peptide content in the hypothalamic paraventricular (PVN) nucleus and exaggerated the consumption of sodium. These results support a physiologic role for adrenomedullin gene products in the central regulation of sodium homeostasis.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)01268-2