Impact of corticosteroid-related symptoms in patients with immune thrombocytopenic purpura: Results of a survey of 985 patients

Abstract Background: Corticosteroid (CS) therapy is effective in many patients with immune thrombocytopenic purpura (ITP), although it is associated with adverse effects. Objective: This study was conducted to describe the CS-related symptom experience of adult patients with ITP and to compare the s...

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Bibliographic Details
Published in:Clinical therapeutics 2008-08, Vol.30 (8), p.1540-1552
Main Authors: Berti, Dana, MSN, Moons, Philip, PhD, RN, Dobbels, Fabienne, PhD, Deuson, Robert, PhD, MS, MSHS, Janssens, Ann, MD, De Geest, Sabina, PhD, RN
Format: Article
Language:English
Subjects:
Adult
adverse effects
Biological and medical sciences
corticosteroids
Data Collection
Female
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Health services
Hematologic and hematopoietic diseases
Hematology
Humans
immune thrombocytopenic purpura
Internal Medicine
Internet
Male
Medical Education
Medical sciences
Middle Aged
Nursing
patient-reported outcomes
Patients
Pharmacology. Drug treatments
Platelet diseases and coagulopathies
Product development
Purpura
Purpura, Thrombocytopenic, Idiopathic - drug therapy
Quality of life
Socioeconomic Factors
Steroids
Stress, Psychological - chemically induced
symptom experience
Time Factors
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Summary:Abstract Background: Corticosteroid (CS) therapy is effective in many patients with immune thrombocytopenic purpura (ITP), although it is associated with adverse effects. Objective: This study was conducted to describe the CS-related symptom experience of adult patients with ITP and to compare the symptom experience of current users of CS, previous users of CS, and those who have never used CS. Methods: In 2006, adult members of the Platelet Disorder Support Association (PDSA) who were listed in the organization's database, resided in the United States, and had a diagnosis of ITP were invited to participate in a Web-based survey. Symptom experience was assessed using 33 CS-related symptoms derived from a scale developed for use in patients undergoing organ transplantation. Symptom experience over the past 4 weeks was measured in terms of the occurrence of symptoms (rated on a 5-point scale from 1 [ never occurring ] to 5 [ always occurring ]) and the distress associated with those symptoms (rated on a 5-point Likert scale from 0 [ not at all distressing ] to 4 [ extremely distressing ]). Respondents were categorized according to 4 patterns of CS use: current users, nonusers, previous users who stopped CS use
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2008.08.005