Loading…
Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa
A white solid compound was isolated from the chloroform extract of the leaves of Senna villosa. The material was identified by 1H-NMR, 13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested in vitro at concentrations of 1.65,...
Saved in:
| Published in: | Phytomedicine (Stuttgart) 2008-10, Vol.15 (10), p.892-895 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153 |
| container_end_page | 895 |
| container_issue | 10 |
| container_start_page | 892 |
| container_title | Phytomedicine (Stuttgart) |
| container_volume | 15 |
| creator | Guzmán, E. Pérez, C. Zavala, M.A. Acosta-Viana, K.Y. Pérez, S. |
| description | A white solid compound was isolated from the chloroform extract of the leaves of
Senna villosa. The material was identified by
1H-NMR,
13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested
in vitro at concentrations of 1.65, 3.3 and 6.6
μg/ml for inhibition of the growth of
Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6
μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6
μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite. |
| doi_str_mv | 10.1016/j.phymed.2008.02.013 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_69581640</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A189219646</galeid><els_id>S094471130800024X</els_id><sourcerecordid>A189219646</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153</originalsourceid><addsrcrecordid>eNp9kV2L1DAUhoMo7rj6D0QKguhFa06bpu3NwrD4BQt7oYJXhkx6upMhTcYkM9j99ZvSQRCGJRcHkufN4ZyHkNdAC6DAP-6K_XYasS9KStuClgWF6glZAYc2p1396ylZ0Y6xvAGoLsiLEHaUAusa-pxcQMsqBtCsyO-1jXrvXXT3TppMqqiPOk6ZG7L3bb6deu_-pi5xOxm0H_LoNWrlgrTTDGOUETMdnEm1zwbvxuw7WiuzozYmYS_Js0GagK9O9ZL8_Pzpx_XX_Ob2y7fr9U2uGK9jjnXNQVZqw5sBAUtV0pa3rOk7kExBK9UgleJ1s-m5rJuy25QN8r6qO1kNFOrqkrxb_k2j_DlgiGLUQaEx0qI7BMG7ugXOaALfLuCdNCi0HVz0Us2wWEPbldBxxhOVn6Hu0KKXxlkcdLr-jy_O8On0OKZ1nQuwJaC8C8HjIPZej9JPAqiY9YqdWPSKWa-gpUh6U-zNaczDZn77Fzr5TMDVAmBa9lGjF0FptAp77VFF0Tv9eIcHjfe4Eg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69581640</pqid></control><display><type>article</type><title>Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa</title><source>Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list)</source><creator>Guzmán, E. ; Pérez, C. ; Zavala, M.A. ; Acosta-Viana, K.Y. ; Pérez, S.</creator><creatorcontrib>Guzmán, E. ; Pérez, C. ; Zavala, M.A. ; Acosta-Viana, K.Y. ; Pérez, S.</creatorcontrib><description>A white solid compound was isolated from the chloroform extract of the leaves of
Senna villosa. The material was identified by
1H-NMR,
13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested
in vitro at concentrations of 1.65, 3.3 and 6.6
μg/ml for inhibition of the growth of
Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6
μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6
μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite.</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2008.02.013</identifier><identifier>PMID: 18434117</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>(8-hydroxymethylen)-trieicosanyl acetate ; Acetates - isolation & purification ; Acetates - pharmacology ; Animals ; Antiprotozoal activity ; Antiprotozoal Agents - isolation & purification ; Antiprotozoal Agents - pharmacology ; Care and treatment ; Chemical properties ; Control ; Dose-Response Relationship, Drug ; Eicosanoids - isolation & purification ; Eicosanoids - pharmacology ; Fabaceae - chemistry ; Health aspects ; Magnetic Resonance Spectroscopy ; Plant Leaves - chemistry ; Senna ; Senna villosa ; Spectrophotometry, Infrared ; Trypanosoma cruzi - chemistry ; Trypanosomiasis</subject><ispartof>Phytomedicine (Stuttgart), 2008-10, Vol.15 (10), p.892-895</ispartof><rights>2008 Elsevier GmbH</rights><rights>COPYRIGHT 2008 Urban & Fischer Verlag</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153</citedby><cites>FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27906,27907</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18434117$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Guzmán, E.</creatorcontrib><creatorcontrib>Pérez, C.</creatorcontrib><creatorcontrib>Zavala, M.A.</creatorcontrib><creatorcontrib>Acosta-Viana, K.Y.</creatorcontrib><creatorcontrib>Pérez, S.</creatorcontrib><title>Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>A white solid compound was isolated from the chloroform extract of the leaves of
Senna villosa. The material was identified by
1H-NMR,
13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested
in vitro at concentrations of 1.65, 3.3 and 6.6
μg/ml for inhibition of the growth of
Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6
μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6
μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite.</description><subject>(8-hydroxymethylen)-trieicosanyl acetate</subject><subject>Acetates - isolation & purification</subject><subject>Acetates - pharmacology</subject><subject>Animals</subject><subject>Antiprotozoal activity</subject><subject>Antiprotozoal Agents - isolation & purification</subject><subject>Antiprotozoal Agents - pharmacology</subject><subject>Care and treatment</subject><subject>Chemical properties</subject><subject>Control</subject><subject>Dose-Response Relationship, Drug</subject><subject>Eicosanoids - isolation & purification</subject><subject>Eicosanoids - pharmacology</subject><subject>Fabaceae - chemistry</subject><subject>Health aspects</subject><subject>Magnetic Resonance Spectroscopy</subject><subject>Plant Leaves - chemistry</subject><subject>Senna</subject><subject>Senna villosa</subject><subject>Spectrophotometry, Infrared</subject><subject>Trypanosoma cruzi - chemistry</subject><subject>Trypanosomiasis</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNp9kV2L1DAUhoMo7rj6D0QKguhFa06bpu3NwrD4BQt7oYJXhkx6upMhTcYkM9j99ZvSQRCGJRcHkufN4ZyHkNdAC6DAP-6K_XYasS9KStuClgWF6glZAYc2p1396ylZ0Y6xvAGoLsiLEHaUAusa-pxcQMsqBtCsyO-1jXrvXXT3TppMqqiPOk6ZG7L3bb6deu_-pi5xOxm0H_LoNWrlgrTTDGOUETMdnEm1zwbvxuw7WiuzozYmYS_Js0GagK9O9ZL8_Pzpx_XX_Ob2y7fr9U2uGK9jjnXNQVZqw5sBAUtV0pa3rOk7kExBK9UgleJ1s-m5rJuy25QN8r6qO1kNFOrqkrxb_k2j_DlgiGLUQaEx0qI7BMG7ugXOaALfLuCdNCi0HVz0Us2wWEPbldBxxhOVn6Hu0KKXxlkcdLr-jy_O8On0OKZ1nQuwJaC8C8HjIPZej9JPAqiY9YqdWPSKWa-gpUh6U-zNaczDZn77Fzr5TMDVAmBa9lGjF0FptAp77VFF0Tv9eIcHjfe4Eg</recordid><startdate>20081001</startdate><enddate>20081001</enddate><creator>Guzmán, E.</creator><creator>Pérez, C.</creator><creator>Zavala, M.A.</creator><creator>Acosta-Viana, K.Y.</creator><creator>Pérez, S.</creator><general>Elsevier GmbH</general><general>Urban & Fischer Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20081001</creationdate><title>Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa</title><author>Guzmán, E. ; Pérez, C. ; Zavala, M.A. ; Acosta-Viana, K.Y. ; Pérez, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>(8-hydroxymethylen)-trieicosanyl acetate</topic><topic>Acetates - isolation & purification</topic><topic>Acetates - pharmacology</topic><topic>Animals</topic><topic>Antiprotozoal activity</topic><topic>Antiprotozoal Agents - isolation & purification</topic><topic>Antiprotozoal Agents - pharmacology</topic><topic>Care and treatment</topic><topic>Chemical properties</topic><topic>Control</topic><topic>Dose-Response Relationship, Drug</topic><topic>Eicosanoids - isolation & purification</topic><topic>Eicosanoids - pharmacology</topic><topic>Fabaceae - chemistry</topic><topic>Health aspects</topic><topic>Magnetic Resonance Spectroscopy</topic><topic>Plant Leaves - chemistry</topic><topic>Senna</topic><topic>Senna villosa</topic><topic>Spectrophotometry, Infrared</topic><topic>Trypanosoma cruzi - chemistry</topic><topic>Trypanosomiasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Guzmán, E.</creatorcontrib><creatorcontrib>Pérez, C.</creatorcontrib><creatorcontrib>Zavala, M.A.</creatorcontrib><creatorcontrib>Acosta-Viana, K.Y.</creatorcontrib><creatorcontrib>Pérez, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Guzmán, E.</au><au>Pérez, C.</au><au>Zavala, M.A.</au><au>Acosta-Viana, K.Y.</au><au>Pérez, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2008-10-01</date><risdate>2008</risdate><volume>15</volume><issue>10</issue><spage>892</spage><epage>895</epage><pages>892-895</pages><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>A white solid compound was isolated from the chloroform extract of the leaves of
Senna villosa. The material was identified by
1H-NMR,
13C-NMR, IR and EM methods as (8-hydroxymethylen)-trieicosanyl acetate, a new compound with biological activity, which was tested
in vitro at concentrations of 1.65, 3.3 and 6.6
μg/ml for inhibition of the growth of
Trypanosoma cruzi epimastigotes and tripomastigotes. We observed inhibition of growth at all concentrations tested, and the effect at concentrations of 3.3 and 6.6
μg/ml was greater than that of gentian violet (positive control). At the concentration of 6.6
μg/ml, the compound showed the greatest inhibitory effect against the growth of both forms of the parasite.</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>18434117</pmid><doi>10.1016/j.phymed.2008.02.013</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2008-10, Vol.15 (10), p.892-895 |
| issn | 0944-7113 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_69581640 |
| source | Elsevier:Jisc Collections:Elsevier Read and Publish Agreement 2022-2024:Freedom Collection (Reading list) |
| subjects | (8-hydroxymethylen)-trieicosanyl acetate Acetates - isolation & purification Acetates - pharmacology Animals Antiprotozoal activity Antiprotozoal Agents - isolation & purification Antiprotozoal Agents - pharmacology Care and treatment Chemical properties Control Dose-Response Relationship, Drug Eicosanoids - isolation & purification Eicosanoids - pharmacology Fabaceae - chemistry Health aspects Magnetic Resonance Spectroscopy Plant Leaves - chemistry Senna Senna villosa Spectrophotometry, Infrared Trypanosoma cruzi - chemistry Trypanosomiasis |
| title | Antiprotozoal activity of (8-hydroxymethylen)-trieicosanyl acetate isolated from Senna villosa |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-17T08%3A29%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Antiprotozoal%20activity%20of%20(8-hydroxymethylen)-trieicosanyl%20acetate%20isolated%20from%20Senna%20villosa&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Guzm%C3%A1n,%20E.&rft.date=2008-10-01&rft.volume=15&rft.issue=10&rft.spage=892&rft.epage=895&rft.pages=892-895&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1016/j.phymed.2008.02.013&rft_dat=%3Cgale_proqu%3EA189219646%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c465t-e5561a3cb67fe1e2c2086847d91a4c18acfacc657bd6a5729b27e6d359a3f0153%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=69581640&rft_id=info:pmid/18434117&rft_galeid=A189219646&rfr_iscdi=true |