Increased levels of human papillomavirus type 16 DNA in a subset of prostate cancers

Whether oncogenic human papilloma viruses (HPVs) are involved in the pathogenesis of prostate cancers has been a subject of great controversy. To clarify the contradictory results of investigations, with the aim of detecting viral nucleic acids in prostate cancers, we have carried out a comparative...

Full description

Saved in:
Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1999-02, Vol.59 (4), p.823-825
Main Authors: SERTH, J, PANITZ, F, PAESLACK, U, KUCZYK, M. A, JONAS, U
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
DNA, Viral - analysis
Human papillomavirus 16
Humans
Male
Medical sciences
Middle Aged
Nephrology. Urinary tract diseases
Papillomaviridae - genetics
Prostatic Hyperplasia - virology
Prostatic Neoplasms - virology
Tumors of the urinary system
Urinary tract. Prostate gland
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Whether oncogenic human papilloma viruses (HPVs) are involved in the pathogenesis of prostate cancers has been a subject of great controversy. To clarify the contradictory results of investigations, with the aim of detecting viral nucleic acids in prostate cancers, we have carried out a comparative quantitation of the HPV16-E6 sequence in 84 prostate specimens. Using single-tube quantitative competitive PCR, we characterized 47 prostate cancers and 37 control tissues of benign prostatic hyperplasia. A subgroup of the prostate tumors (10 of 47; 21%) was detected as having significantly higher copy numbers of HPV16-E6 sequences when compared to the control tissue (1 of 37; 3%), using a cutoff value of 300 copies per 12,500 diploid cells (two-sided Fisher's exact test, P = 0.02). Our results indicate that the oncogenic HPV16 might contribute to the development of a subset of prostate tumors.
ISSN:0008-5472
1538-7445