G20210A mutation in prothrombin gene and risk of myocardial infarction, stroke, and venous thrombosis in a large cohort of US men

A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. In a prospective cohort of 14 916 men, we det...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-03, Vol.99 (8), p.999-1004
Main Authors: RIDKER, P. M, HENNEKENS, C. H, MILETICH, J. P
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Cardiology. Vascular system
Cerebrovascular Disorders - etiology
Cohort Studies
Coronary heart disease
Factor V - genetics
Heart
Humans
Male
Medical sciences
Middle Aged
Mutation
Myocardial Infarction - etiology
Prospective Studies
Prothrombin - genetics
Risk Factors
Venous Thrombosis - etiology
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Summary:A single base pair mutation in the prothrombin gene has recently been identified that is associated with increased prothrombin levels. Whether this mutation increases the risks of arterial and venous thrombosis among healthy individuals is controversial. In a prospective cohort of 14 916 men, we determined the prevalence of the G20210A prothrombin gene variant in 833 men who subsequently developed myocardial infarction, stroke, or venous thrombosis (cases) and in 1774 age- and smoking status-matched men who remained free of thrombosis during a 10-year follow-up (control subjects). Gene sequencing was used to confirm mutation status in a subgroup of participants. Overall, carrier rates for the G20210A mutation were similar among case and control subjects; the relative risk of developing any thrombotic event in association with the 20210A allele was 1.05 (95% CI, 0.7 to 1.6; P=0.8). We observed no evidence of association between mutation and myocardial infarction (RR=0.8, P=0.4) or stroke (RR=1.1, P=0.8). For venous thrombosis, a modest nonsignificant increase in risk was observed (RR=1.7, P=0.08) that was smaller in magnitude than that associated with factor V Leiden (RR=3.0, P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.99.8.999