Nonanticoagulant heparin prevents coronary endothelial dysfunction after brief ischemia-reperfusion injury in the dog

Coronary endothelial dysfunction after brief ischemia-reperfusion (IR) remains a clinical problem. We investigated the role of heparin and N-acetylheparin, a nonanticoagulant heparin derivative, in modulating coronary endothelial function after IR injury, with an emphasis on defining the role of the...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-03, Vol.99 (8), p.1062-1068
Main Authors: KOURETAS, P. C, KIM, Y. D, CAHILL, P. A, MYERS, A. K, TO, L. N, WANG, Y.-N, SITZMANN, J. V, HANNAN, R. L
Format: Article
Language:English
Subjects:
Animals
Anticoagulants - therapeutic use
Biological and medical sciences
Blood Coagulation
Cardiology. Vascular system
Coronary heart disease
Coronary Vessels - drug effects
Coronary Vessels - physiopathology
Cyclic GMP - analysis
Dogs
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Heart
Heparin - therapeutic use
Male
Medical sciences
Myocardial Ischemia - drug therapy
Myocardial Reperfusion Injury - drug therapy
Myocardial Reperfusion Injury - physiopathology
Nitrates - analysis
Nitric Oxide - physiology
Nitrites - analysis
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Summary:Coronary endothelial dysfunction after brief ischemia-reperfusion (IR) remains a clinical problem. We investigated the role of heparin and N-acetylheparin, a nonanticoagulant heparin derivative, in modulating coronary endothelial function after IR injury, with an emphasis on defining the role of the nitric oxide (NO)-cGMP pathway in the heparin-mediated effect. Male mongrel dogs were surgically instrumented, and the effects of both bovine heparin and N-acetylheparin on coronary endothelial vasomotor function, expressed as percent change from baseline flow after acetylcholine challenge, were studied after 15 minutes of regional ischemia of the left anterior descending artery (LAD) followed by 120 minutes of reperfusion. In dogs treated with placebo (saline), coronary vasomotor function was significantly (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.99.8.1062