N-terminal proatrial natriuretic peptide in angina pectoris: impact of revascularization by angioplasty

Aims. We investigated whether levels of N-terminal proatrial natriuretic peptide (N-terminal proANP) reflect the severity of coronary artery disease in chronic, stable angina pectoris. Furthermore, we investigated if revascularization by percutaneous transluminal coronary angioplasty (PTCA) affected...

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Bibliographic Details
Published in:International journal of cardiology 1999, Vol.68 (1), p.1-8
Main Authors: Klinge, Randi, Jørgensen, Bjørn, Thaulow, Erik, Sirnes, Per Anton, Hall, Christian
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Amlodipine - therapeutic use
Angina Pectoris - blood
Angina Pectoris - etiology
Angina Pectoris - physiopathology
Angioplasty
Angioplasty, Balloon, Coronary
Atrial Natriuretic Factor - blood
Atrial natriuretic peptide
Biological and medical sciences
Calcium Channel Blockers - therapeutic use
Chronic Disease
Coronary disease
Coronary Disease - blood
Coronary Disease - complications
Coronary Disease - prevention & control
Creatinine - blood
Diseases of the cardiovascular system
Double-Blind Method
Female
Humans
Linear Models
Male
Medical sciences
Middle Aged
Myocardial Revascularization
Prospective Studies
Protein Precursors - blood
Radioimmunoassay
Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects)
Statistics, Nonparametric
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Summary:Aims. We investigated whether levels of N-terminal proatrial natriuretic peptide (N-terminal proANP) reflect the severity of coronary artery disease in chronic, stable angina pectoris. Furthermore, we investigated if revascularization by percutaneous transluminal coronary angioplasty (PTCA) affected the N-terminal proANP level and, finally, whether restenosis could be predicted by changes in N-terminal proANP after PTCA. Methods and results. N-terminal proANP was measured in 286 patients before and after PTCA. The patients' baseline level of N-terminal proANP (787±403 pmol/l) correlated significantly with left ventricular end diastolic pressure, age and serum creatinine, but not with the number of stenotic vessels. Twenty-four hours post-PTCA N-terminal proANP decreased significantly, and completely revascularized patients demonstrated a decline two-fold larger than those incompletely revascularized (ΔN-terminal proANP −114±178 vs. −53±231 pmol/l, P
ISSN:0167-5273
1874-1754
DOI:10.1016/S0167-5273(98)00342-8