Continuous arterial P(O2) and P(CO2) measurements in swine during nitrous oxide and xenon elimination: prevention of diffusion hypoxia

During nitrous oxide (N2O) elimination, arterial oxygen tension (PaO2) decreases because of the phenomenon commonly called diffusive hypoxia. The authors questioned whether similar effects occur during xenon elimination. Nineteen anesthetized and paralyzed pigs were mechanically ventilated randomly...

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Bibliographic Details
Published in:Anesthesiology (Philadelphia) 1999-03, Vol.90 (3), p.829-834
Main Authors: Calzia, E, Stahl, W, Handschuh, T, Marx, T, Fröba, G, Georgieff, M, Rademacher, P
Format: Article
Language:English
Subjects:
Anesthetics, Inhalation - administration & dosage
Animals
Blood Gas Analysis
Carbon Dioxide - blood
Nitrous Oxide - administration & dosage
Oxygen - blood
Partial Pressure
Pulmonary Gas Exchange - drug effects
Pulmonary Gas Exchange - physiology
Respiration, Artificial
Swine
Xenon - administration & dosage
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Summary:During nitrous oxide (N2O) elimination, arterial oxygen tension (PaO2) decreases because of the phenomenon commonly called diffusive hypoxia. The authors questioned whether similar effects occur during xenon elimination. Nineteen anesthetized and paralyzed pigs were mechanically ventilated randomly for 30 min using inspiratory gas mixtures of 30% oxygen and either 70% N2O or xenon. The inspiratory gas was replaced by a mixture of 70% nitrogen and 30% oxygen. PaO2 and carbon dioxide tensions were recorded continuously using an indwelling arterial sensor. The PaO2 decreased from 119+/-10 mm Hg to 102+/-12 mm Hg (mean+/-SD) during N2O washout (P
ISSN:0003-3022
DOI:10.1097/00000542-199903000-00026