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Breath analysis in patients with end-stage renal disease: effect of haemodialysis
ABSTRACT Background There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients. To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured i...
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| Published in: | European journal of clinical investigation 2008-10, Vol.38 (10), p.728-733 |
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| creator | Rolla, G. Bruno, M. Bommarito, L. Heffler, E. Ferrero, N. Petrarulo, M. Bagnis, C. Bugiani, M. Guida, G. |
| description | ABSTRACT
Background There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients.
To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured in addition to FENO, taking into account the influence on these markers of airway pH, which may be regulated by ammonia (), present in large amounts in the breath of ESRD patients and removed by HD.
Study design FENO and NO metabolites (NOx, , ), pH and in EBC were measured in 12 ESRD patients, before and after HD. Twelve healthy subjects acted as controls.
Results FENO values of ESRD patients were similar to normals, while EBC‐NOx, , and pH were significantly higher in ESRD patients compared to normals (EBC‐NOx 12·3, range 11·1–41·9 µm vs. 9·4, range 4·6–10·9 µm, P = 0·007; 4·70, range 1·17–8·22 µm vs. 0·90, range 0·72–1·17 µm, P = 0·023; 2340, range 1325–3922 µm vs. 660, range 406–872 µm, P |
| doi_str_mv | 10.1111/j.1365-2362.2008.02016.x |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_69638328</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>69638328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4356-b8c25e076ab9abf63b7248660b5d4b72f81425f2fe9410343134a784b93c9d5e3</originalsourceid><addsrcrecordid>eNqNkE1r3DAQhkVpaDZJ_0LRJb3Z0ZdlKdBDs6T5JCHQUuhFyPao0dZrbyUv2f33leNle40uGpjnnRkehDAlOU3vbJFTLouMcclyRojKCSNU5pt3aLZvvEczQqjImC7ZITqKcUESSTn7gA6pUrwstZqhp4sAdnjGtrPtNvqIfYdXdvDQDRG_-NSBrsniYH8DDpAg3PgINsI5BuegHnDv8LOFZd_4acIJOnC2jfBx9x-jH98uv8-vs_vHq5v51_usFryQWaVqVgAppa20rZzkVcmEkpJURSNS7RQVrHDMgRaUcMEpF7ZUotK81k0B_Bh9nuauQv93DXEwSx9raFvbQb-ORmrJFWcqgWoC69DHGMCZVfBLG7aGEjPqNAszWjOjNTPqNK86zSZFP-12rKslNP-DO38JON0BNta2dcF2tY97jhGZjlA8cV8m7sW3sH3zAeZyfjNWKZ9NeR8H2OzzNvwxsuRlYX4-XBmuL6j4davNHf8HoHGefQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>69638328</pqid></control><display><type>article</type><title>Breath analysis in patients with end-stage renal disease: effect of haemodialysis</title><source>Wiley</source><creator>Rolla, G. ; Bruno, M. ; Bommarito, L. ; Heffler, E. ; Ferrero, N. ; Petrarulo, M. ; Bagnis, C. ; Bugiani, M. ; Guida, G.</creator><creatorcontrib>Rolla, G. ; Bruno, M. ; Bommarito, L. ; Heffler, E. ; Ferrero, N. ; Petrarulo, M. ; Bagnis, C. ; Bugiani, M. ; Guida, G.</creatorcontrib><description>ABSTRACT
Background There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients.
To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured in addition to FENO, taking into account the influence on these markers of airway pH, which may be regulated by ammonia (), present in large amounts in the breath of ESRD patients and removed by HD.
Study design FENO and NO metabolites (NOx, , ), pH and in EBC were measured in 12 ESRD patients, before and after HD. Twelve healthy subjects acted as controls.
Results FENO values of ESRD patients were similar to normals, while EBC‐NOx, , and pH were significantly higher in ESRD patients compared to normals (EBC‐NOx 12·3, range 11·1–41·9 µm vs. 9·4, range 4·6–10·9 µm, P = 0·007; 4·70, range 1·17–8·22 µm vs. 0·90, range 0·72–1·17 µm, P = 0·023; 2340, range 1325–3922 µm vs. 660, range 406–872 µm, P < 0·001; pH 7·16, range 6·82–7·44 vs. 6·60, range 6·42–6·76, P = 0·004, respectively). HD caused a mild significant decrease of FENO, and normalization of , NOx, and pH. A significant positive relationship between EBC‐pH and EBC‐ before and after HD (r2 = 0·65, P = 0·000) was observed, explaining higher than normal EBC‐pH before HD, while no relationship was found between EBC‐pH and FENO or NO metabolites.
Conclusion Oxidative stress, and not EBC‐pH, is the most probable cause of increased NO metabolites in ESRD patients before HD.</description><identifier>ISSN: 0014-2972</identifier><identifier>EISSN: 1365-2362</identifier><identifier>DOI: 10.1111/j.1365-2362.2008.02016.x</identifier><identifier>PMID: 18837798</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Airway ammonia ; airway pH ; Ammonia - analysis ; Biological and medical sciences ; Biomarkers - analysis ; Breath Tests ; Case-Control Studies ; end-stage renal disease ; exhaled breath condensate ; exhaled nitric oxide ; Female ; General aspects ; haemodialysis ; Humans ; Hydrogen-Ion Concentration ; Kidney Failure, Chronic - metabolism ; Kidney Failure, Chronic - therapy ; Male ; Medical sciences ; Middle Aged ; Nephrology. Urinary tract diseases ; Nephropathies. Renovascular diseases. Renal failure ; Nitrates - analysis ; Nitric Oxide - analysis ; Nitrites - analysis ; Nitrogen Dioxide - analysis ; Renal Dialysis ; Renal failure ; Statistics, Nonparametric</subject><ispartof>European journal of clinical investigation, 2008-10, Vol.38 (10), p.728-733</ispartof><rights>2008 The Authors. Journal Compilation © 2008 Blackwell Publishing Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4356-b8c25e076ab9abf63b7248660b5d4b72f81425f2fe9410343134a784b93c9d5e3</citedby><cites>FETCH-LOGICAL-c4356-b8c25e076ab9abf63b7248660b5d4b72f81425f2fe9410343134a784b93c9d5e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20663883$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18837798$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rolla, G.</creatorcontrib><creatorcontrib>Bruno, M.</creatorcontrib><creatorcontrib>Bommarito, L.</creatorcontrib><creatorcontrib>Heffler, E.</creatorcontrib><creatorcontrib>Ferrero, N.</creatorcontrib><creatorcontrib>Petrarulo, M.</creatorcontrib><creatorcontrib>Bagnis, C.</creatorcontrib><creatorcontrib>Bugiani, M.</creatorcontrib><creatorcontrib>Guida, G.</creatorcontrib><title>Breath analysis in patients with end-stage renal disease: effect of haemodialysis</title><title>European journal of clinical investigation</title><addtitle>Eur J Clin Invest</addtitle><description>ABSTRACT
Background There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients.
To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured in addition to FENO, taking into account the influence on these markers of airway pH, which may be regulated by ammonia (), present in large amounts in the breath of ESRD patients and removed by HD.
Study design FENO and NO metabolites (NOx, , ), pH and in EBC were measured in 12 ESRD patients, before and after HD. Twelve healthy subjects acted as controls.
Results FENO values of ESRD patients were similar to normals, while EBC‐NOx, , and pH were significantly higher in ESRD patients compared to normals (EBC‐NOx 12·3, range 11·1–41·9 µm vs. 9·4, range 4·6–10·9 µm, P = 0·007; 4·70, range 1·17–8·22 µm vs. 0·90, range 0·72–1·17 µm, P = 0·023; 2340, range 1325–3922 µm vs. 660, range 406–872 µm, P < 0·001; pH 7·16, range 6·82–7·44 vs. 6·60, range 6·42–6·76, P = 0·004, respectively). HD caused a mild significant decrease of FENO, and normalization of , NOx, and pH. A significant positive relationship between EBC‐pH and EBC‐ before and after HD (r2 = 0·65, P = 0·000) was observed, explaining higher than normal EBC‐pH before HD, while no relationship was found between EBC‐pH and FENO or NO metabolites.
Conclusion Oxidative stress, and not EBC‐pH, is the most probable cause of increased NO metabolites in ESRD patients before HD.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Airway ammonia</subject><subject>airway pH</subject><subject>Ammonia - analysis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - analysis</subject><subject>Breath Tests</subject><subject>Case-Control Studies</subject><subject>end-stage renal disease</subject><subject>exhaled breath condensate</subject><subject>exhaled nitric oxide</subject><subject>Female</subject><subject>General aspects</subject><subject>haemodialysis</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Kidney Failure, Chronic - metabolism</subject><subject>Kidney Failure, Chronic - therapy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Nephropathies. Renovascular diseases. Renal failure</subject><subject>Nitrates - analysis</subject><subject>Nitric Oxide - analysis</subject><subject>Nitrites - analysis</subject><subject>Nitrogen Dioxide - analysis</subject><subject>Renal Dialysis</subject><subject>Renal failure</subject><subject>Statistics, Nonparametric</subject><issn>0014-2972</issn><issn>1365-2362</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkE1r3DAQhkVpaDZJ_0LRJb3Z0ZdlKdBDs6T5JCHQUuhFyPao0dZrbyUv2f33leNle40uGpjnnRkehDAlOU3vbJFTLouMcclyRojKCSNU5pt3aLZvvEczQqjImC7ZITqKcUESSTn7gA6pUrwstZqhp4sAdnjGtrPtNvqIfYdXdvDQDRG_-NSBrsniYH8DDpAg3PgINsI5BuegHnDv8LOFZd_4acIJOnC2jfBx9x-jH98uv8-vs_vHq5v51_usFryQWaVqVgAppa20rZzkVcmEkpJURSNS7RQVrHDMgRaUcMEpF7ZUotK81k0B_Bh9nuauQv93DXEwSx9raFvbQb-ORmrJFWcqgWoC69DHGMCZVfBLG7aGEjPqNAszWjOjNTPqNK86zSZFP-12rKslNP-DO38JON0BNta2dcF2tY97jhGZjlA8cV8m7sW3sH3zAeZyfjNWKZ9NeR8H2OzzNvwxsuRlYX4-XBmuL6j4davNHf8HoHGefQ</recordid><startdate>200810</startdate><enddate>200810</enddate><creator>Rolla, G.</creator><creator>Bruno, M.</creator><creator>Bommarito, L.</creator><creator>Heffler, E.</creator><creator>Ferrero, N.</creator><creator>Petrarulo, M.</creator><creator>Bagnis, C.</creator><creator>Bugiani, M.</creator><creator>Guida, G.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200810</creationdate><title>Breath analysis in patients with end-stage renal disease: effect of haemodialysis</title><author>Rolla, G. ; Bruno, M. ; Bommarito, L. ; Heffler, E. ; Ferrero, N. ; Petrarulo, M. ; Bagnis, C. ; Bugiani, M. ; Guida, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4356-b8c25e076ab9abf63b7248660b5d4b72f81425f2fe9410343134a784b93c9d5e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Airway ammonia</topic><topic>airway pH</topic><topic>Ammonia - analysis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - analysis</topic><topic>Breath Tests</topic><topic>Case-Control Studies</topic><topic>end-stage renal disease</topic><topic>exhaled breath condensate</topic><topic>exhaled nitric oxide</topic><topic>Female</topic><topic>General aspects</topic><topic>haemodialysis</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Kidney Failure, Chronic - metabolism</topic><topic>Kidney Failure, Chronic - therapy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Nephropathies. Renovascular diseases. Renal failure</topic><topic>Nitrates - analysis</topic><topic>Nitric Oxide - analysis</topic><topic>Nitrites - analysis</topic><topic>Nitrogen Dioxide - analysis</topic><topic>Renal Dialysis</topic><topic>Renal failure</topic><topic>Statistics, Nonparametric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rolla, G.</creatorcontrib><creatorcontrib>Bruno, M.</creatorcontrib><creatorcontrib>Bommarito, L.</creatorcontrib><creatorcontrib>Heffler, E.</creatorcontrib><creatorcontrib>Ferrero, N.</creatorcontrib><creatorcontrib>Petrarulo, M.</creatorcontrib><creatorcontrib>Bagnis, C.</creatorcontrib><creatorcontrib>Bugiani, M.</creatorcontrib><creatorcontrib>Guida, G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rolla, G.</au><au>Bruno, M.</au><au>Bommarito, L.</au><au>Heffler, E.</au><au>Ferrero, N.</au><au>Petrarulo, M.</au><au>Bagnis, C.</au><au>Bugiani, M.</au><au>Guida, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Breath analysis in patients with end-stage renal disease: effect of haemodialysis</atitle><jtitle>European journal of clinical investigation</jtitle><addtitle>Eur J Clin Invest</addtitle><date>2008-10</date><risdate>2008</risdate><volume>38</volume><issue>10</issue><spage>728</spage><epage>733</epage><pages>728-733</pages><issn>0014-2972</issn><eissn>1365-2362</eissn><abstract>ABSTRACT
Background There is no agreement about exhaled nitric oxide (FENO) and its change after haemodialysis (HD) in end‐stage renal disease (ESRD) patients.
To comprehensively assess NO production in the respiratory system, NO metabolites in exhaled breath condensate (EBC) needs to be measured in addition to FENO, taking into account the influence on these markers of airway pH, which may be regulated by ammonia (), present in large amounts in the breath of ESRD patients and removed by HD.
Study design FENO and NO metabolites (NOx, , ), pH and in EBC were measured in 12 ESRD patients, before and after HD. Twelve healthy subjects acted as controls.
Results FENO values of ESRD patients were similar to normals, while EBC‐NOx, , and pH were significantly higher in ESRD patients compared to normals (EBC‐NOx 12·3, range 11·1–41·9 µm vs. 9·4, range 4·6–10·9 µm, P = 0·007; 4·70, range 1·17–8·22 µm vs. 0·90, range 0·72–1·17 µm, P = 0·023; 2340, range 1325–3922 µm vs. 660, range 406–872 µm, P < 0·001; pH 7·16, range 6·82–7·44 vs. 6·60, range 6·42–6·76, P = 0·004, respectively). HD caused a mild significant decrease of FENO, and normalization of , NOx, and pH. A significant positive relationship between EBC‐pH and EBC‐ before and after HD (r2 = 0·65, P = 0·000) was observed, explaining higher than normal EBC‐pH before HD, while no relationship was found between EBC‐pH and FENO or NO metabolites.
Conclusion Oxidative stress, and not EBC‐pH, is the most probable cause of increased NO metabolites in ESRD patients before HD.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18837798</pmid><doi>10.1111/j.1365-2362.2008.02016.x</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Airway ammonia airway pH Ammonia - analysis Biological and medical sciences Biomarkers - analysis Breath Tests Case-Control Studies end-stage renal disease exhaled breath condensate exhaled nitric oxide Female General aspects haemodialysis Humans Hydrogen-Ion Concentration Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - therapy Male Medical sciences Middle Aged Nephrology. Urinary tract diseases Nephropathies. Renovascular diseases. Renal failure Nitrates - analysis Nitric Oxide - analysis Nitrites - analysis Nitrogen Dioxide - analysis Renal Dialysis Renal failure Statistics, Nonparametric |
| title | Breath analysis in patients with end-stage renal disease: effect of haemodialysis |
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