Dose-dependent antibody response to influenza H1N1 vaccine component in elderly nursing home patients

The effects of an increased antigen dose on HI, IgG, IgA, and IgM antibody responses to influenza A/Taiwan/1/86 (H1N1) were investigated in 92 elderly nursing-home residents (mean age 81 years) and 104 young subjects (mean age 20 years). At a standard 10-μg dose, HI and IgG titer rises were lower in...

Full description

Saved in:
Bibliographic Details
Published in:Experimental gerontology 1999, Vol.34 (1), p.109-115
Main Authors: Remarque, E.J., de Jong, J.M.A., van der Klis, R.J., Masurel, N., Ligthart, G.J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Aging - immunology
Antibodies, Viral - blood
Antibody Specificity
dose response
Dose-Response Relationship, Immunologic
elderly
Humans
immunogenicity
Immunoglobulin A - blood
Immunoglobulin G - blood
Immunoglobulin M - blood
influenza
Influenza Vaccines - immunology
Nursing Homes
Vaccination
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of an increased antigen dose on HI, IgG, IgA, and IgM antibody responses to influenza A/Taiwan/1/86 (H1N1) were investigated in 92 elderly nursing-home residents (mean age 81 years) and 104 young subjects (mean age 20 years). At a standard 10-μg dose, HI and IgG titer rises were lower in the elderly. HI titers did not improve at higher vaccine dosages. By contrast, influenza-specific IgG and IgA antibody responses were dose dependent in elderly subjects, but not in young. In the young subjects, IgM antibody responses were dose dependent. The improved antibody responses in the elderly as observed in IgG and IgA were not reflected in the HI response. Therefore, the evaluation of antibody production by HI only may lead to an underestimate of the immune response in elderly people.
ISSN:0531-5565
1873-6815
DOI:10.1016/S0531-5565(98)00060-6