Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis

We identified connexins 26 and 32 in human oral mucosa. The presence of the connexins indicates the presence of gap junctions in this tissue. However, immunofluorescence study found no significant differences in the expression of the connexins between patients with aphthons stomatitis and controls....

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Bibliographic Details
Published in:Journal of gastroenterology 1999-02, Vol.34 (1), p.1-6
Main Authors: Hara, A, Murata, T, Uemura, R, Miura, T, Fukui, K, Matsukawa, H, Kasiwagi, K, Ito, T, Yoshioka, M, Hibi, T
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Ulcer Agents - therapeutic use
Cell Communication
Connexins - metabolism
Female
Fluorescent Antibody Technique
Follow-Up Studies
Gap Junctions - drug effects
Gap Junctions - metabolism
Humans
Male
Middle Aged
Mouth Mucosa - cytology
Mouth Mucosa - drug effects
Mouth Mucosa - metabolism
Secondary Prevention
Stomatitis, Aphthous - drug therapy
Stomatitis, Aphthous - metabolism
Stomatitis, Aphthous - pathology
Triazines - therapeutic use
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Summary:We identified connexins 26 and 32 in human oral mucosa. The presence of the connexins indicates the presence of gap junctions in this tissue. However, immunofluorescence study found no significant differences in the expression of the connexins between patients with aphthons stomatitis and controls. Irsogladine maleate, which reinforces gap junctional intercellular communication in vitro, was effective for the treatment of transient and relapsing aphthous stomatitis, as well as symptomatic and drug-induced aphthous stomatitis. It was also useful for prevention of episodes of relapsing aphthous stomatitis, with daily administration preverting recurrence of stomatitis for more than 4 years one patient. These findings suggest that irsogladine maleate accelerates the wound healing process in oral mucosa by reinforcing gap junctional intercellular communication among oral mucosal cells; and that it is useful for the treatment and prevention of aphthous stomatitis.
ISSN:0944-1174
1435-5922
DOI:10.1007/s005350050208