Inhibition of epidural fibrosis with ADCON-L: effect on clinical outcome one year following re-operation for recurrent lumbar radiculopathy

In a prospective multicenter study, 20 patients underwent re-operation for recurrent radiculopathy after lumbo-sacral discectomy, and were treated with ADCON-L (Adhesion Control in a Barrier Gel) to inhibit epidural fibrosis following secondary surgery. Outcomes after re-operation were assessed at s...

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Bibliographic Details
Published in:Neurological research (New York) 1999, Vol.21 Suppl 1, p.S51-S60
Main Authors: Porchet, F, Lombardi, D, de Preux, J, Pople, I K
Format: Article
Language:English
Subjects:
Adult
Diskectomy - adverse effects
Epidural Space
Female
Fibrosis - prevention & control
Follow-Up Studies
Gels - therapeutic use
Humans
Male
Organic Chemicals
Postoperative Complications - prevention & control
Prospective Studies
Recurrence
Reoperation
Spinal Nerve Roots - drug effects
Surveys and Questionnaires
Treatment Outcome
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Summary:In a prospective multicenter study, 20 patients underwent re-operation for recurrent radiculopathy after lumbo-sacral discectomy, and were treated with ADCON-L (Adhesion Control in a Barrier Gel) to inhibit epidural fibrosis following secondary surgery. Outcomes after re-operation were assessed at six and 12 months using: Visual Analog Scales to measure radicular and back pain, straight leg raising exams, and self-assessment of activity-related radicular pain. Each parameter was compared to baseline values, obtained immediately prior to the re-operation. The long term clinical results at 12 months after re-operation (summarized below) demonstrate a significant improvement of all clinical parameters, and correlated with the results seen at six months. Radicular pain, measured when most severe, was reduced from an average pre-operative score of 8.1-3.7 (p < 0.005). The straight leg raising angle increased from an average pre-operative value of 41 degrees-67 degrees (p < 0.005). Activity-related pain mean score was 4.6, vs. 17.0 pre-operatively (p < 0.005). Low back pain, measured when most severe, was reduced from an average pre-operative score of 6.1 to 3.1 (p < 0.012). These clinical findings compare very favorably with data reported in the literature. There were no adverse events or complications related to the use of ADCON-L.
ISSN:0161-6412
1743-1328
DOI:10.1080/01616412.1999.11741028