Malignant lymphoma of the gastrointestinal tract

AimsThe gastrointestinal tract (GIT) is the most common site of extra-nodal lymphoma. Most of these lymphomas arise from mucosa associated lymphoid tissue (MALT). We attempt in this study to define the natural history and treatment outcome of this type of lymphoma.MethodsWe carried out a retrospecti...

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Bibliographic Details
Published in:European journal of surgical oncology 1999-04, Vol.25 (2), p.164-167
Main Authors: Pandey, M., Wadhwa, M.K., Patel, H.P., Kothari, K.C., Shah, M., Patel, .D D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Diagnosis, Differential
Disease-Free Survival
duodenum
Gastroenterology. Liver. Pancreas. Abdomen
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - mortality
Gastrointestinal Neoplasms - therapy
gastrointestinal tract
Hematologic and hematopoietic diseases
Humans
India
Intestinal Neoplasms
Intestine, Small
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Lymphoma, Non-Hodgkin - diagnosis
Lymphoma, Non-Hodgkin - mortality
Lymphoma, Non-Hodgkin - therapy
Medical sciences
mucosa associated lymphoid tissue
non-Hodgkin's lymphoma
Retrospective Studies
small bowel
stomach
Stomach Neoplasms
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumors
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Summary:AimsThe gastrointestinal tract (GIT) is the most common site of extra-nodal lymphoma. Most of these lymphomas arise from mucosa associated lymphoid tissue (MALT). We attempt in this study to define the natural history and treatment outcome of this type of lymphoma.MethodsWe carried out a retrospective study of patients presenting at our centre with histopathological diagnosis of primary GIT lymphoma between 1990 and 1994.ResultsEqual numbers of cases of stomach and small bowel lymphoma were found. Vomiting and feeling of fullness were the two most common presenting symptoms. Large cell type and high grade tumours were found to be the commonest histological types. All the patients were treated with surgery followed by chemotherapy. A 5-year disease-free survival (DFS) rate of 73% was observed with a confidence interval of 0.65–1.35. Survival in stomach cancer was 73.5% (95% CI 0.26–1.74) while it was 76.4% in small bowel tumours (95% CI 0.54–1.46). The difference in survival was not statistically significant.ConclusionsAlthough there is no consensus regarding treatment of primary GI lymphoma, surgery and adjuvant chemotherapy yield good survival.
ISSN:0748-7983
1532-2157
DOI:10.1053/ejso.1998.0620