Evaluation of three lines of immunodeficient mice for the study of spontaneous metastatic tumors

Various immunodeficient animals have been used as transplantation recipients for studying the growth of human tumors. We have been assessing the value of immunodeficiencies for the study of naturally arising tumors, using a model system of transgenic mice that spontaneously develop cancer of the pan...

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Published in:APMIS : acta pathologica, microbiologica et immunologica Scandinavica microbiologica et immunologica Scandinavica, 1999-03, Vol.107 (1-6), p.245-256
Main Authors: GALLO-HENDRIKX, ELEANOR, PERCY, DEAN, COPPS, JOHN, McKEOWN, BRENDAN, QUINTON, MARGARET, McMILLAN, IAN, CROY, B. ANNE, WILDEMAN, ALAN G.
Format: Article
Language:English
Subjects:
Adenocarcinoma - pathology
Adenocarcinoma - secondary
Animal tumors. Experimental tumors
Animals
Antigens, Polyomavirus Transforming - genetics
beige
Biological and medical sciences
cancer
Disease Models, Animal
Female
immunodeficient
Male
Medical sciences
metastasis
Mice
Mice, Inbred C57BL
Mice, SCID
Mice, Transgenic
Pancreas
Pancreatic Neoplasms - pathology
SCID
Spontaneous animal tumors
T antigen
Tumors
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Summary:Various immunodeficient animals have been used as transplantation recipients for studying the growth of human tumors. We have been assessing the value of immunodeficiencies for the study of naturally arising tumors, using a model system of transgenic mice that spontaneously develop cancer of the pancreas as a result of elastase promoter‐driven expression of the large tumor antigen gene of simian virus 40. We previously reported the establishment of transgenic mice that carried the SCID and/or beige mutations, eliminating B‐and T‐cell function and reducing lytic NK cell activity, respectively. In SCID beige animals, metastasis rates and target organs for metastases were similar to those observed in humans with pancreatic cancer. We describe here analysis of subsequent more highly inbred generations of these mice. The data show that inbreeding has almost negated the value of these immunodeficiencies for enhancing disease progression, and we observe high rates of metastasis even in immunocompetent animals. The data suggest that SCID and beige immunodeficiencies may not always have the same value for the modeling of spontaneous tumors as they do for the study of xenografts.
ISSN:0903-4641
1600-0463
DOI:10.1111/j.1699-0463.1999.tb01551.x