Tumor blood volume assays using contrast-enhanced magnetic resonance imaging: Regional heterogeneity and postmortem artifacts

Tumor blood volume (BV), subject to both morphologic and physiologic influences, can be measured using contrast‐enhanced magnetic resonance imaging (MRI). The aims of this study were to determine whether MRI enhanced with a macromolecular contrast medium (MMCM) could resolve differences in BV betwee...

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Bibliographic Details
Published in:Journal of magnetic resonance imaging 1999-05, Vol.9 (5), p.685-690
Main Authors: Okuhata, Yoshitaka, Brasch, Robert C., Pham, Christine D., Daldrup, Heike, Wendland, Michael F., Shames, David M., Roberts, Timothy P.L.
Format: Article
Language:English
Subjects:
Albumins
Animals
blood volume
cancer
Contrast Media
Female
Gadolinium DTPA
Image Processing, Computer-Assisted
macromolecular
Magnetic Resonance Imaging - methods
Mammary Neoplasms, Experimental - blood supply
Mammary Neoplasms, Experimental - pathology
microvascularity control media
MRI
Neoplasm Transplantation
Rats
Rats, Inbred F344
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Summary:Tumor blood volume (BV), subject to both morphologic and physiologic influences, can be measured using contrast‐enhanced magnetic resonance imaging (MRI). The aims of this study were to determine whether MRI enhanced with a macromolecular contrast medium (MMCM) could resolve differences in BV between different tumor types, between different regions within tumors, and within the same tumor in life and after death. Tumor BV estimates were based on the MRI signal intensity responses in the tumors and in reference venous blood following enhancement with a blood pool MMCM using two mammary adenocarcinoma models. Estimates of BV were made before and immediately following death. An in vitro measurement of tumor gadolinium concentration following death was correlated with MRI enhancement. Statistically significant differences (P 
ISSN:1053-1807
1522-2586
DOI:10.1002/(SICI)1522-2586(199905)9:5<685::AID-JMRI10>3.0.CO;2-#