Changes in endothelial function and its association with plasma osteoprotegerin in hypothyroidism with exercise-induced silent myocardial ischaemia

Summary Objective  Hypothyroidism is associated with an increased risk for cardiovascular disease. Exercise‐induced silent myocardial ischaemia (SI) is an early stage of coronary artery disease. Recently, many studies have shown that endothelial dysfunction is an early physiological event in atheros...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2008-11, Vol.69 (5), p.799-803
Main Authors: Guang-da, Xiang, Hui-ling, Sun, Jie, Hou
Format: Article
Language:English
Subjects:
Biological and medical sciences
Blood Pressure - physiology
Cardiology. Vascular system
Case-Control Studies
Coronary heart disease
Endocrinopathies
Endothelium, Vascular - physiopathology
Exercise - physiology
Female
Fundamental and applied biological sciences. Psychology
Heart
Humans
Hypothyroidism - blood
Hypothyroidism - complications
Hypothyroidism - physiopathology
Lipids - blood
Medical sciences
Middle Aged
Myocardial Ischemia - blood
Myocardial Ischemia - complications
Myocardial Ischemia - etiology
Myocardial Ischemia - physiopathology
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Osteoprotegerin - blood
Risk Factors
Thyroid. Thyroid axis (diseases)
Vertebrates: endocrinology
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Summary:Summary Objective  Hypothyroidism is associated with an increased risk for cardiovascular disease. Exercise‐induced silent myocardial ischaemia (SI) is an early stage of coronary artery disease. Recently, many studies have shown that endothelial dysfunction is an early physiological event in atherosclerosis, and osteoprotegerin (OPG) acts as an important regulatory molecule in the vasculature. The aim of this study was to investigate the alteration of endothelial function and its association with plasma OPG in hypothyroidism with SI. Methods  Forty‐eight female postmenopausal hypothyroid patients with normal rest electrocardiography (ECG) were selected. Of these, 19 cases had SI. Twenty healthy females without SI were selected as controls. High‐resolution ultrasound was used to measure brachial artery diameter at rest, after reactive hyperaemia and after sublingual glyceryltrinitrate (GTN). Plasma OPG concentration was measured in duplicate by a sandwich enzyme‐linked immunosorbent assay (ELISA). Results  Flow‐mediated arterial dilation (FMD) in the total hypothyroid group, the hypothyroidism with SI group and the hypothyroidism without SI group was 3·51 ± 0·62%, 3·20 ± 0·54% and 3·72 ± 0·60%, respectively, significantly lower than that in the controls (5·08 ± 0·61%) (P 
ISSN:0300-0664
1365-2265
DOI:10.1111/j.1365-2265.2008.03263.x