Increased sympathetic nerve activity in renovascular hypertension

Increased sympathetic nerve activity may contribute to the progression of renovascular hypertension. Because previous results have been inconclusive, we investigated whether renovascular hypertensives show increased total and regional sympathetic nerve activity. Sixty-five patients underwent renal a...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1999-05, Vol.99 (19), p.2537-2542
Main Authors: JOHANSSON, M, ELAM, M, RUNDQVIST, B, EISENHOFER, G, HERLITZ, H, LAMBERT, G, FRIBERG, P
Format: Article
Language:English
Subjects:
Angiography
Angiotensin II - blood
Arterial hypertension. Arterial hypotension
Biological and medical sciences
Blood and lymphatic vessels
Cardiology. Vascular system
Clinical manifestations. Epidemiology. Investigative techniques. Etiology
Female
Humans
Hypertension, Renovascular - blood
Hypertension, Renovascular - physiopathology
Kidney - blood supply
Kidney - innervation
Kidney - physiopathology
Male
Medical sciences
Middle Aged
Renin - blood
Sympathetic Nervous System - physiopathology
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Summary:Increased sympathetic nerve activity may contribute to the progression of renovascular hypertension. Because previous results have been inconclusive, we investigated whether renovascular hypertensives show increased total and regional sympathetic nerve activity. Sixty-five patients underwent renal angiography and measurements of plasma renin activity and angiotensin II in conjunction with estimation of sympathetic nerve activity by means of radiotracer dilution and intraneural recordings of muscle sympathetic nerve activity (MSNA). Age-matched healthy subjects (n=15) were examined for comparison. Total body norepinephrine (NE) spillover, an index of overall sympathetic nerve activity, was increased by 100% and MSNA by 60% in the hypertensive patients compared with healthy subjects (P
ISSN:0009-7322
1524-4539
DOI:10.1161/01.cir.99.19.2537