Plasma urokinase receptor levels in patients with colorectal cancer : Relationship to prognosis

The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1999-05, Vol.91 (10), p.869-874
Main Authors: STEPHENS, R. W, NIELSEN, H. J, CHRISTENSEN, I. J, THORLACIUS-USSING, O, SØRENSEN, S, DANØ, K, BRÜNNER, N
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Biological and medical sciences
Biomarkers, Tumor - blood
Carcinoembryonic Antigen - blood
Colorectal cancer
Colorectal Neoplasms - blood
Enzyme Precursors - blood
Female
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Male
Medical research
Medical sciences
Middle Aged
Neoplasm Staging
Plasma
Plasminogen Activators - blood
Predictive Value of Tests
Prognosis
Proportional Hazards Models
Receptors, Cell Surface - blood
Receptors, Urokinase Plasminogen Activator
Retrospective Studies
Risk
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Survival Analysis
Tumors
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Summary:The proteolytic enzyme plasmin, which is generated from the precursor plasminogen by the action of urokinase plasminogen activator, is thought to play a role in tumor cell invasion and metastasis. Urokinase plasminogen activator receptor (uPAR) is functionally involved in the cell surface activation (i.e., cleavage) of plasminogen. Increased tumor tissue levels of uPAR are associated with poor prognosis in several types of cancer. This retrospective study was undertaken to test the relationship between preoperative plasma levels of soluble uPAR (suPAR) and survival in patients with colorectal cancer. suPAR levels in preoperative plasma from 591 patients with colorectal cancer were determined by use of a kinetic enzyme-linked immunosorbent assay and analyzed with respect to associations with postoperative survival, Dukes' stage, age, and serum carcinoembryonic antigen level. Plasma suPAR measurements were log transformed for survival analysis, which employed the Kaplan-Meier method and the Cox proportional hazards model. All P values reported are two-sided. Univariate analysis, using the log-transformed suPAR concentrations, demonstrated that there was an increasing risk of mortality with increasing plasma suPAR level (P
ISSN:0027-8874
1460-2105
1460-2105
DOI:10.1093/jnci/91.10.869