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Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters
Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plas...
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| Published in: | Journal of food science 2008-11, Vol.73 (9), p.H235-H240 |
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| Main Authors: | , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c4863-1cc03971fb2d59ef9bce6ad7baac2c6bc35f9a39a1f7a03bad9800607d4027ff3 |
| container_end_page | H240 |
| container_issue | 9 |
| container_start_page | H235 |
| container_title | Journal of food science |
| container_volume | 73 |
| creator | Frota, K.M.G Mendonça, S Saldiva, P.H.N Cruz, R.J Arêas, J.A.G |
| description | Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plasma total cholesterol and non-HDL cholesterol. HPI and HC presented similar protein digestibility, which were significantly higher than that of HWS. Animals fed on HWS presented significantly higher levels of bile acids and cholesterol in feces than did the animals fed on casein or HPI diets. Histological analyses of the liver showed that HC diet resulted in steatosis widely distributed throughout the hepatic lobule, while HWS and HPI diets promoted reductions in liver steatosis. The effectiveness of HWS for modulating lipid metabolism was greater than that of HPI, as measured by plasma cholesterol reduction and liver steatosis. |
| doi_str_mv | 10.1111/j.1750-3841.2008.00953.x |
| format | article |
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Hamsters fed on HWS and HPI presented significant reductions in plasma total cholesterol and non-HDL cholesterol. HPI and HC presented similar protein digestibility, which were significantly higher than that of HWS. Animals fed on HWS presented significantly higher levels of bile acids and cholesterol in feces than did the animals fed on casein or HPI diets. Histological analyses of the liver showed that HC diet resulted in steatosis widely distributed throughout the hepatic lobule, while HWS and HPI diets promoted reductions in liver steatosis. The effectiveness of HWS for modulating lipid metabolism was greater than that of HPI, as measured by plasma cholesterol reduction and liver steatosis.</description><identifier>ISSN: 0022-1147</identifier><identifier>EISSN: 1750-3841</identifier><identifier>DOI: 10.1111/j.1750-3841.2008.00953.x</identifier><identifier>PMID: 19021807</identifier><identifier>CODEN: JFDSAZ</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>animal disease models ; Animals ; Anticholesteremic Agents - pharmacology ; bile acids ; Bile Acids and Salts - metabolism ; Biological and medical sciences ; blood lipids ; casein ; cholesteremic effect ; Cholesterol ; Cholesterol, Dietary - metabolism ; cowpea ; cowpeas ; Cricetinae ; dietary fat ; Dietary Fiber - pharmacology ; digestible protein ; Digestion ; Energy Intake ; Fabaceae ; Fatty acids ; fatty liver ; feces ; Food industries ; Fundamental and applied biological sciences. Psychology ; hamsters ; Histology ; hypercholesterolemia ; Hypercholesterolemia - blood ; Hypercholesterolemia - metabolism ; hypocholesterolemia ; lipid metabolism ; Lipids - blood ; Lipoproteins - blood ; Liver ; Male ; Mesocricetus ; Metabolism ; Plant Proteins - pharmacology ; protein isolate ; protein isolates ; Proteins ; Rodents ; saturated fatty acids ; Seeds ; steatosis ; Triglycerides - blood ; whole seeds</subject><ispartof>Journal of food science, 2008-11, Vol.73 (9), p.H235-H240</ispartof><rights>2008 Institute of Food Technologists</rights><rights>2008 INIST-CNRS</rights><rights>Copyright Institute of Food Technologists Nov/Dec 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4863-1cc03971fb2d59ef9bce6ad7baac2c6bc35f9a39a1f7a03bad9800607d4027ff3</citedby><cites>FETCH-LOGICAL-c4863-1cc03971fb2d59ef9bce6ad7baac2c6bc35f9a39a1f7a03bad9800607d4027ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20859867$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19021807$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frota, K.M.G</creatorcontrib><creatorcontrib>Mendonça, S</creatorcontrib><creatorcontrib>Saldiva, P.H.N</creatorcontrib><creatorcontrib>Cruz, R.J</creatorcontrib><creatorcontrib>Arêas, J.A.G</creatorcontrib><title>Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters</title><title>Journal of food science</title><addtitle>J Food Sci</addtitle><description>Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plasma total cholesterol and non-HDL cholesterol. HPI and HC presented similar protein digestibility, which were significantly higher than that of HWS. Animals fed on HWS presented significantly higher levels of bile acids and cholesterol in feces than did the animals fed on casein or HPI diets. Histological analyses of the liver showed that HC diet resulted in steatosis widely distributed throughout the hepatic lobule, while HWS and HPI diets promoted reductions in liver steatosis. The effectiveness of HWS for modulating lipid metabolism was greater than that of HPI, as measured by plasma cholesterol reduction and liver steatosis.</description><subject>animal disease models</subject><subject>Animals</subject><subject>Anticholesteremic Agents - pharmacology</subject><subject>bile acids</subject><subject>Bile Acids and Salts - metabolism</subject><subject>Biological and medical sciences</subject><subject>blood lipids</subject><subject>casein</subject><subject>cholesteremic effect</subject><subject>Cholesterol</subject><subject>Cholesterol, Dietary - metabolism</subject><subject>cowpea</subject><subject>cowpeas</subject><subject>Cricetinae</subject><subject>dietary fat</subject><subject>Dietary Fiber - pharmacology</subject><subject>digestible protein</subject><subject>Digestion</subject><subject>Energy Intake</subject><subject>Fabaceae</subject><subject>Fatty acids</subject><subject>fatty liver</subject><subject>feces</subject><subject>Food industries</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>hamsters</subject><subject>Histology</subject><subject>hypercholesterolemia</subject><subject>Hypercholesterolemia - blood</subject><subject>Hypercholesterolemia - metabolism</subject><subject>hypocholesterolemia</subject><subject>lipid metabolism</subject><subject>Lipids - blood</subject><subject>Lipoproteins - blood</subject><subject>Liver</subject><subject>Male</subject><subject>Mesocricetus</subject><subject>Metabolism</subject><subject>Plant Proteins - pharmacology</subject><subject>protein isolate</subject><subject>protein isolates</subject><subject>Proteins</subject><subject>Rodents</subject><subject>saturated fatty acids</subject><subject>Seeds</subject><subject>steatosis</subject><subject>Triglycerides - blood</subject><subject>whole seeds</subject><issn>0022-1147</issn><issn>1750-3841</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNqNkV9v0zAUxS0EYmXwFcBCgreE6zh_7Acepo5uRWUgyjTerBvHHilpXOxU7b49Dq2KxBN-8bX8O0fHx4RQBimL690qZVUBCRc5SzMAkQLIgqf7R2RyunhMJgBZljCWV2fkWQgrGM-8fErOmISMCagm5Pv0h-tMGIx3XbJwO-Pb_p5-8W5j_NCaQJ2ldyNCp263MUiXxjQU-4bOhzByg2l7Og-uw8HQOF7jenQLz8kTi10wL477Obmdffg2vU4Wn6_m04tFonNR8oRpDVxWzNZZU0hjZa1NiU1VI-pMl7XmhZXIJTJbIfAaGykASqiaHLLKWn5O3h58N9792saXqHUbtOk67I3bBlVKwTgHiODrf8CV2_o-ZlNM5jmTkskIiQOkvQvBG6s2vl2jf1AM1Fi9WqmxYTU2rMbq1Z_q1T5KXx79t_XaNH-Fx64j8OYIYNDYWY-9bsOJy0AUUpQj9_7A7drOPPx3APVxdrmMU9QnB30bP2J_0qP_qaJ7Vai7myt1U3yF8vLTTInIvzrwFp3Cex8z3S4zYBxYEYsWOf8NnYa29w</recordid><startdate>200811</startdate><enddate>200811</enddate><creator>Frota, K.M.G</creator><creator>Mendonça, S</creator><creator>Saldiva, P.H.N</creator><creator>Cruz, R.J</creator><creator>Arêas, J.A.G</creator><general>Blackwell Publishing Inc</general><general>Institute of Food Technologists</general><general>Wiley Subscription Services, Inc</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QR</scope><scope>7ST</scope><scope>7T7</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>F28</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>200811</creationdate><title>Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters</title><author>Frota, K.M.G ; Mendonça, S ; Saldiva, P.H.N ; Cruz, R.J ; Arêas, J.A.G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4863-1cc03971fb2d59ef9bce6ad7baac2c6bc35f9a39a1f7a03bad9800607d4027ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>animal disease models</topic><topic>Animals</topic><topic>Anticholesteremic Agents - pharmacology</topic><topic>bile acids</topic><topic>Bile Acids and Salts - metabolism</topic><topic>Biological and medical sciences</topic><topic>blood lipids</topic><topic>casein</topic><topic>cholesteremic effect</topic><topic>Cholesterol</topic><topic>Cholesterol, Dietary - metabolism</topic><topic>cowpea</topic><topic>cowpeas</topic><topic>Cricetinae</topic><topic>dietary fat</topic><topic>Dietary Fiber - pharmacology</topic><topic>digestible protein</topic><topic>Digestion</topic><topic>Energy Intake</topic><topic>Fabaceae</topic><topic>Fatty acids</topic><topic>fatty liver</topic><topic>feces</topic><topic>Food industries</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>hamsters</topic><topic>Histology</topic><topic>hypercholesterolemia</topic><topic>Hypercholesterolemia - blood</topic><topic>Hypercholesterolemia - metabolism</topic><topic>hypocholesterolemia</topic><topic>lipid metabolism</topic><topic>Lipids - blood</topic><topic>Lipoproteins - blood</topic><topic>Liver</topic><topic>Male</topic><topic>Mesocricetus</topic><topic>Metabolism</topic><topic>Plant Proteins - pharmacology</topic><topic>protein isolate</topic><topic>protein isolates</topic><topic>Proteins</topic><topic>Rodents</topic><topic>saturated fatty acids</topic><topic>Seeds</topic><topic>steatosis</topic><topic>Triglycerides - blood</topic><topic>whole seeds</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frota, K.M.G</creatorcontrib><creatorcontrib>Mendonça, S</creatorcontrib><creatorcontrib>Saldiva, P.H.N</creatorcontrib><creatorcontrib>Cruz, R.J</creatorcontrib><creatorcontrib>Arêas, J.A.G</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Environment Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ANTE: Abstracts in New Technology & Engineering</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of food science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frota, K.M.G</au><au>Mendonça, S</au><au>Saldiva, P.H.N</au><au>Cruz, R.J</au><au>Arêas, J.A.G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters</atitle><jtitle>Journal of food science</jtitle><addtitle>J Food Sci</addtitle><date>2008-11</date><risdate>2008</risdate><volume>73</volume><issue>9</issue><spage>H235</spage><epage>H240</epage><pages>H235-H240</pages><issn>0022-1147</issn><eissn>1750-3841</eissn><coden>JFDSAZ</coden><abstract>Hypercholesterolemic hamsters were fed for 4 wk on diets rich in saturated fatty acids and cholesterol, differing only in protein source (20 %): casein (control group, HC), whole cowpea seed (HWS), and cowpea protein isolate (HPI). Hamsters fed on HWS and HPI presented significant reductions in plasma total cholesterol and non-HDL cholesterol. HPI and HC presented similar protein digestibility, which were significantly higher than that of HWS. Animals fed on HWS presented significantly higher levels of bile acids and cholesterol in feces than did the animals fed on casein or HPI diets. Histological analyses of the liver showed that HC diet resulted in steatosis widely distributed throughout the hepatic lobule, while HWS and HPI diets promoted reductions in liver steatosis. The effectiveness of HWS for modulating lipid metabolism was greater than that of HPI, as measured by plasma cholesterol reduction and liver steatosis.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>19021807</pmid><doi>10.1111/j.1750-3841.2008.00953.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of food science, 2008-11, Vol.73 (9), p.H235-H240 |
| issn | 0022-1147 1750-3841 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | animal disease models Animals Anticholesteremic Agents - pharmacology bile acids Bile Acids and Salts - metabolism Biological and medical sciences blood lipids casein cholesteremic effect Cholesterol Cholesterol, Dietary - metabolism cowpea cowpeas Cricetinae dietary fat Dietary Fiber - pharmacology digestible protein Digestion Energy Intake Fabaceae Fatty acids fatty liver feces Food industries Fundamental and applied biological sciences. Psychology hamsters Histology hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - metabolism hypocholesterolemia lipid metabolism Lipids - blood Lipoproteins - blood Liver Male Mesocricetus Metabolism Plant Proteins - pharmacology protein isolate protein isolates Proteins Rodents saturated fatty acids Seeds steatosis Triglycerides - blood whole seeds |
| title | Cholesterol-Lowering Properties of Whole Cowpea Seed and Its Protein Isolate in Hamsters |
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