Esomeprazole reduces gastroesophageal reflux after beer consumption in healthy volunteers

Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux sympto...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 2008, Vol.43 (12), p.1425-1431
Main Authors: Franke, Andreas, Hepp, Caroline, Harder, Hermann, Beglinger, Christoph, Singer, Manfred V.
Format: Article
Language:English
Subjects:
Adult
Beer - adverse effects
Biological and medical sciences
Digestive system
Double-Blind Method
Esomeprazole - pharmacology
Esomeprazole - therapeutic use
Esophageal disorders
Esophageal pH Monitoring
Esophagus
Gastroenterology. Liver. Pancreas. Abdomen
Gastroesophageal Reflux - drug therapy
Gastroesophageal Reflux - etiology
Humans
Male
Medical sciences
motility
nutrition
Other diseases. Semiology
Pharmacology. Drug treatments
Proton Pump Inhibitors - pharmacology
Proton Pump Inhibitors - therapeutic use
Treatment Outcome
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Summary:Objective. Patients with gastroesophageal reflux disease (GERD) are advised to avoid alcoholic beverages since alcohol consumption induces gastroesophageal reflux in healthy volunteers and increases it in patients with GERD. Proton-pump inhibitors (PPIs) are frequently administered for reflux symptoms but their effect on gastroesophageal reflux after alcohol consumption has not yet been fully studied. The aim of the present study was therefore to investigate the effect of esomeprazole, an S-enantiomer of omeprazole, on gastroesophageal reflux after beer consumption. Material and methods. In this placebo-controlled, double-blind, crossover study, 16 healthy male volunteers received 20 mg esomeprazole daily for one week. On day 7, in an acute experiment, the subjects then consumed 500 ml beer within 5 min. Subsequently, gastroesophageal reflux was monitored by pH-metry over a period of 3 h. In addition, gastric emptying was measured by ultrasonography and blood concentrations of ethanol, cholecystokinin and gastrin were determined. Results. Gastroesophageal reflux was significantly (p=0.001) reduced by 93% after treatment with esomeprazole (0.2%, median percentage of time pH
ISSN:0036-5521
1502-7708
DOI:10.1080/00365520802105110