Analysis of hepatitis B virus X gene phylogeny, genetic variability and its impact on pathogenesis: Implications in Eastern Indian HBV carriers

Abstract HBx genetic variability was explored in the Eastern Indian population with low HCC incidence. DNase I sensitive HBV DNA was detected in 53% samples, which differed significantly between clinical groups ( P < 0.001). HBV genotypes A (Aa/A1), C (Cs/C1) and D (D1, D2, D3, D5) were detected...

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Published in:Virology (New York, N.Y.) N.Y.), 2008-12, Vol.382 (2), p.190-198
Main Authors: Datta, Sibnarayan, Banerjee, Arup, Chandra, Partha Kumar, Biswas, Avik, Panigrahi, Rajesh, Mahapatra, Pradip Kumar, Panda, Chinmoy Kumar, Chakrabarti, Shekhar, Bhattacharya, Sujit Kumar, Chakravarty, Runu
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Amino Acid Substitution
Base Sequence
Carrier State - virology
Consensus Sequence
DNA, Viral - blood
DNA, Viral - genetics
Eastern India
Evolution, Molecular
Genetic Variation
Genotype
HBV DNA
Hepatitis B genotypes
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis B virus - isolation & purification
Hepatitis B virus - pathogenicity
Hepatitis B, Chronic - virology
Humans
India
Infectious Disease
Molecular Sequence Data
Mutation
Phylogeny
Polymorphism, Single Nucleotide
Protein Structure, Tertiary
Sequence Homology, Amino Acid
Trans-Activators - chemistry
Trans-Activators - genetics
Virulence - genetics
X gene
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Summary:Abstract HBx genetic variability was explored in the Eastern Indian population with low HCC incidence. DNase I sensitive HBV DNA was detected in 53% samples, which differed significantly between clinical groups ( P < 0.001). HBV genotypes A (Aa/A1), C (Cs/C1) and D (D1, D2, D3, D5) were detected in 37.5%, 18.7% and 43.7% samples respectively. Population specific signature HBx residues A36 , V88 , S101 in Aa/A1 and residues P41 , Q110 in D5 were detected. Mutations T127 , M130 and I131 were detected in 66.7%, 91% and 75% of genotype A, C and D5 samples respectively. Very low occurrence of HCC associated mutations (V5 M/L, P38 S, and H94 Y) and absence of C-terminal deletions were observed. Our study shows that HBV genotype associated clinically important HBx variations may evolve and act distinctly in different geo-ethnic populations. Further studies on HBx functions from the perspective of genetic variability are essential for the better understanding of the clinical significance of HBV.
ISSN:0042-6822
1096-0341
DOI:10.1016/j.virol.2008.09.007