Aging exacerbates extrapyramidal motor signs in the era of highly active antiretroviral therapy

The phenotype of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) in the developed world has changed with the broad institution of highly active antiretroviral theray (HAART) and with aging of the HIV+ population. Extrapyramidal motor signs were a prominent feature of HA...

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Bibliographic Details
Published in:Journal of neurovirology 2008-01, Vol.14 (5), p.362-367
Main Authors: Valcour, Victor, Watters, Michael R, Williams, Andrew E, Sacktor, Ned, McMurtray, Aaron, Shikuma, Cecilia
Format: Article
Language:English
Subjects:
Adult
Aging
AIDS Dementia Complex - diagnosis
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretroviral Therapy, Highly Active
Antiviral agents
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cognition Disorders - diagnosis
Cohort Studies
Female
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - virology
HIV-1
Human immunodeficiency virus
Human viral diseases
Humans
Immunology
Infectious Diseases
Male
Medical sciences
Middle Aged
Motor Skills Disorders - complications
Motor Skills Disorders - diagnosis
Neurologic Examination
Neurology
Neurosciences
Pharmacology. Drug treatments
Viral diseases
Viral diseases of the nervous system
Virology
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Summary:The phenotype of human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) in the developed world has changed with the broad institution of highly active antiretroviral theray (HAART) and with aging of the HIV+ population. Extrapyramidal motor signs were a prominent feature of HAND as defined in the early stages of the epidemic but has not been reevaluated in the era of HAART. Moreover, the contribution of aging to extrapyramidal motor signs in the context of HIV remains undefined. We examined these questions among the 229 HIV+ participants in the Hawaii Aging with HIV Cohort compared to age-, gender-, and ethnicity-matched HIV-negative controls. Extrapyramidal motor signs were quantified using the motor exam of the Unified Parkinson's Disease Rating Scale (UPDRSmotor) and compared to concurrent neuropsychological and clinical cognitive diagnostic categorization. The mean UPDRSmotor score increased with older age (1.68 versus 3.35; P
ISSN:1355-0284
1538-2443
DOI:10.1080/13550280802216494