Dark spots in late-phase indocyanine green angiographic studies in a patient with presumed ocular histoplasmosis syndrome

We analyzed indocyanine green (ICG) angiograms in a patient with presumed ocular histoplasmosis syndrome (POHS) complaining about "seeing spots" and decreased visual acuity in order to identify the pathologic process. A 30-year-old caucasian man with clinical signs of POHS who had previous...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 1999-06, Vol.237 (6), p.524-526
Main Authors: WEINBERGER, A. W. A, KUBE, T, WOLF, S
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Choroidal Neovascularization - complications
Choroidal Neovascularization - diagnosis
Choroiditis - complications
Choroiditis - diagnosis
Diagnosis, Differential
Fluorescein Angiography
Histoplasmoses
Histoplasmosis - complications
Histoplasmosis - diagnosis
Human mycoses
Humans
Indocyanine Green
Infectious diseases
Male
Medical sciences
Mycoses
Retinal Diseases - complications
Retinal Diseases - diagnosis
Scotoma - etiology
Tropical mycoses
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Summary:We analyzed indocyanine green (ICG) angiograms in a patient with presumed ocular histoplasmosis syndrome (POHS) complaining about "seeing spots" and decreased visual acuity in order to identify the pathologic process. A 30-year-old caucasian man with clinical signs of POHS who had previously undergone laser photocoagulation for secondary choroidal neovascularization developed visual disturbances primarily in his temporal visual field. We performed fundus photography, fluorescein angiography and ICG angiography before, during and after the episode of visual disturbance. ICG angiographic findings were correlated to fundus photographs and fluorescein angiograms. Fundus examination, fluorescein angiograms and early-phase ICG angiograms were unremarkable at all time points. However, during the phase of visual disturbance, late-phase ICG angiographic study revealed hypofluorescent lesions in the area representing the visual disturbances. At 1 week follow-up, these hypofluorescent lesions were reduced in size and number; at 6 months follow-up they had completely resolved. Late-phase ICG angiographic study can provide additional information in inflammatory retinal disease by virtue of identifying areas of choroidal alterations while standard diagnostic examination remain unremarkable.
ISSN:0721-832X
1435-702X
DOI:10.1007/s004170050274