National Academy of Clinical Biochemistry Laboratory Medicine Practice Guidelines for Use of Tumor Markers in Testicular, Prostate, Colorectal, Breast, and Ovarian Cancers

Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been developed. Published reports relevant to use of tumor markers for 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critical...

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Published in:Clinical chemistry (Baltimore, Md.) Md.), 2008-12, Vol.54 (12), p.e11-e79
Main Authors: Sturgeon, Catharine M, Duffy, Michael J, Stenman, Ulf-Hakan, Lilja, Hans, Brunner, Nils, Chan, Daniel W, Babaian, Richard, Bast, Robert C., Jr, Dowell, Barry, Esteva, Francisco J, Haglund, Caj, Harbeck, Nadia, Hayes, Daniel F, Holten-Andersen, Mads, Klee, George G, Lamerz, Rolf, Looijenga, Leendert H, Molina, Rafael, Nielsen, Hans Jorgen, Rittenhouse, Harry, Semjonow, Axel, Shih, Ie-Ming, Sibley, Paul, Soletormos, Gyorgy, Stephan, Carsten, Sokoll, Lori, Hoffman, Barry R, Diamandis, Eleftherios P
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Breast Neoplasms - diagnosis
Clinical Laboratory Techniques - standards
Colorectal Neoplasms - diagnosis
Female
Humans
Male
Ovarian Neoplasms - diagnosis
Prostatic Neoplasms - diagnosis
Reference Values
Testicular Neoplasms - diagnosis
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Summary:Updated National Academy of Clinical Biochemistry (NACB) Laboratory Medicine Practice Guidelines for the use of tumor markers in the clinic have been developed. Published reports relevant to use of tumor markers for 5 cancer sites--testicular, prostate, colorectal, breast, and ovarian--were critically reviewed. For testicular cancer, alpha-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase are recommended for diagnosis/case finding, staging, prognosis determination, recurrence detection, and therapy monitoring. alpha-Fetoprotein is also recommended for differential diagnosis of nonseminomatous and seminomatous germ cell tumors. Prostate-specific antigen (PSA) is not recommended for prostate cancer screening, but may be used for detecting disease recurrence and monitoring therapy. Free PSA measurement data are useful for distinguishing malignant from benign prostatic disease when total PSA is
ISSN:0009-9147
1530-8561
DOI:10.1373/clinchem.2008.105601