Somatosensory feedback from the limbs exerts inhibitory influences on central neural drive during whole body endurance exercise

• Published in: Journal of applied physiology (1985) 2008-12, Vol.105 (6), p.1714-1724
• Main Authors: Amann, Markus, Proctor, Lester T, Sebranek, Joshua J, Eldridge, Marlowe W, Pegelow, David F, Dempsey, Jerome A
• Format: Article
• Language: English
• Subjects: Adult; Afferent Pathways - physiology; Algorithms; Anesthesia; Anesthesia, Epidural; Anesthetics, Local - pharmacology; Bicycling - physiology; Biological and medical sciences; Central Nervous System - physiology; Clinical trials; Electromyography; Exercise; Exercise - physiology; Extremities - innervation; Extremities - physiology; Feedback - physiology; Fundamental and applied biological sciences. Psychology; Humans; Lidocaine - pharmacology; Male; Motor ability; Muscle, Skeletal - drug effects; Muscle, Skeletal - innervation; Muscle, Skeletal - physiology; Neurons, Afferent - physiology; Physical Endurance - physiology; Pulmonary Gas Exchange - physiology; Reproducibility of Results; Respiratory Mechanics - physiology; Senses; Young Adult
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.90456.2008

1 John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin-Madison Medical School, Madison, Wisconsin; 2 University of Zürich, Institute of Physiology, and ETH Zürich, Exercise Physiology, Zürich, Switzerland; and 3 Department of Anesthesiology, University of Wisconsin-Madison Medical School, Madison, Wisconsin Submitted 27 March 2008 ; accepted in final form 4 September 2008 We investigated whether somatosensory feedback from contracting limb muscles exerts an inhibitory influence on the determination of central command during closed-loop cycling exercise in which the subject voluntarily determines his second-by-second central motor drive. Eight trained cyclists performed two 5-km time trials either without (5K Ctrl ) or with lumbar epidural anesthesia (5K Epi ; 24 ml of 0.5% lidocaine, vertebral interspace L 3 –L 4 ). Percent voluntary quadriceps muscle activation was determined at rest using a superimposed twitch technique. Epidural lidocaine reduced pretime trial maximal voluntary quadriceps strength (553 ± 45 N) by 22 ± 3%. Percent voluntary quadriceps activation was also reduced from 97 ± 1% to 81 ± 3% via epidural lidocaine, and this was unchanged following the 5K Epi , indicating the presence of a sustained level of neural impairment throughout the trial. Power output was reduced by 9 ± 2% throughout the race ( P < 0.05). We found three types of significant effects of epidural lidocaine that supported a substantial role for somatosensory feedback from the exercising limbs as a determinant of central command throughout high-intensity closed-loop cycling exercise: 1 ) significantly increased relative integrated EMG of the vastus lateralis; 2 ) similar pedal forces despite the reduced number of fast-twitch muscle fibers available for activation; 3 ) and increased ventilation out of proportion to a reduced carbon dioxide production and heart rate and increased blood pressure out of proportion to power output and oxygen consumption. These findings demonstrate the inhibitory influence of somatosensory feedback from contracting locomotor muscles on the conscious and/or subconscious determination of the magnitude of central motor drive during high intensity closed-loop endurance exercise. nociception; control of breathing; exercise hyperpnea; cardiorespiratory response; muscle metaboreflex; ascending sensory pathway Address for reprint requests and other correspondence: M. Amann, Institute of Physiology, Univ. of Zürich, and Institute for Exer