Smoking and Airway Hyperresponsiveness Especially in the Presence of Blood Eosinophilia Increase the Risk to Develop Respiratory Symptoms . A 25-year Follow-up Study in the General Adult Population

Airway hyperresponsiveness (AHR) constitutes a risk for development of respiratory symptoms. We assessed whether blood eosinophilia (>/= 275 eosinophils/microliters), skin test positivity (sum score >/= 3) and cigarette smoking (never, ex-smoker, 1-14 cig/d, 15-24 cig/d, >/= 25 cig/d) at th...

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Published in:American journal of respiratory and critical care medicine 1999-07, Vol.160 (1), p.259-264
Main Authors: JANSEN, DESIREE F, SCHOUTEN, JAN P, VONK, JUDITH M, RIJCKEN, BERT, TIMENS, WIM, KRAAN, JAN, WEISS, SCOTT T, POSTMA, DIRKJE S
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Bronchi - physiopathology
Bronchial Hyperreactivity - physiopathology
Eosinophilia - physiopathology
Female
Follow-Up Studies
Forced Expiratory Volume - physiology
Humans
Longitudinal Studies
Lung Diseases, Obstructive - physiopathology
Male
Medical sciences
Middle Aged
Risk Factors
Smoking - adverse effects
Smoking - physiopathology
Tobacco, tobacco smoking
Toxicology
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Summary:Airway hyperresponsiveness (AHR) constitutes a risk for development of respiratory symptoms. We assessed whether blood eosinophilia (>/= 275 eosinophils/microliters), skin test positivity (sum score >/= 3) and cigarette smoking (never, ex-smoker, 1-14 cig/d, 15-24 cig/d, >/= 25 cig/d) at the first of two successive surveys are related to the development of respiratory symptoms (chronic cough or phlegm, bronchitis, persistent wheeze, dyspnea, and asthma) at the second survey, and whether these relations are the same in subjects with (PC10
ISSN:1073-449X
1535-4970
DOI:10.1164/ajrccm.160.1.9811015