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Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency
Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. T...
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| Published in: | The journal of clinical endocrinology and metabolism 1999-07, Vol.84 (7), p.2373-2380 |
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| container_issue | 7 |
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| container_title | The journal of clinical endocrinology and metabolism |
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| creator | TER MAATEN, J. C DE BOER, H KAMP, O STUURMAN, L VAN DER VEEN, E. A |
| description | Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. Thirty-eight men with childhood-onset GH deficiency were studied for a period of 3-5 yr. Measurements included anthropometry, computed tomographic scanning of abdomen and upper leg, bone densitometry, echo cardiography, and bicycle ergometry. The initial GH dose of 1-3 IU/m2 x day (9-27 microg/kg) was gradually tapered to 1.30+/-0.38 IU/m2 x day (11 g/kg), aiming at physiological insulin-like growth factor I levels. During the study, leg muscle mass progressively increased by 28.7% (P |
| doi_str_mv | 10.1210/jc.84.7.2373 |
| format | article |
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C ; DE BOER, H ; KAMP, O ; STUURMAN, L ; VAN DER VEEN, E. A</creator><creatorcontrib>TER MAATEN, J. C ; DE BOER, H ; KAMP, O ; STUURMAN, L ; VAN DER VEEN, E. A</creatorcontrib><description><![CDATA[Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. Thirty-eight men with childhood-onset GH deficiency were studied for a period of 3-5 yr. Measurements included anthropometry, computed tomographic scanning of abdomen and upper leg, bone densitometry, echo cardiography, and bicycle ergometry. The initial GH dose of 1-3 IU/m2 x day (9-27 microg/kg) was gradually tapered to 1.30+/-0.38 IU/m2 x day (11 g/kg), aiming at physiological insulin-like growth factor I levels. During the study, leg muscle mass progressively increased by 28.7% (P<0.001). Subcutaneous and intraabdominal fat decreased by 30.9% and 46.0%, respectively, after 1 yr (both P<0.001), but demonstrated a partial regain thereafter. Bone mineral density at the lumbar spine, femoral neck, and trochanter gradually increased by 9.6%, 11.1%, and 16.2%, respectively (all P<0.001). Left ventricular mass exceeded baseline values by 14.1% after 1 yr (P<0.001), but returned to pretreatment values thereafter. Stroke volume and cardiac output increased by 16.3% (P = 0.002) and 33.4% (P<0.001), respectively. Maximal work load increased from 189+/-30 to 232+/-41 watts (P<0.001). Thus, long term GH replacement is safe and beneficial. It improves cardiac performance without inducing left ventricular hypertrophy and progressively increases bone mineral density.]]></description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/jc.84.7.2373</identifier><identifier>PMID: 10404806</identifier><identifier>CODEN: JCEMAZ</identifier><language>eng</language><publisher>Bethesda, MD: Endocrine Society</publisher><subject>Adult ; Anthropometry ; Biological and medical sciences ; Blood Pressure ; Body Composition - drug effects ; Bone Density - drug effects ; Echocardiography ; Heart - drug effects ; Heart - physiology ; Heart Rate ; Hormones. Endocrine system ; Human Growth Hormone - administration & dosage ; Human Growth Hormone - adverse effects ; Human Growth Hormone - deficiency ; Humans ; Insulin-Like Growth Factor I - metabolism ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Skinfold Thickness ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>The journal of clinical endocrinology and metabolism, 1999-07, Vol.84 (7), p.2373-2380</ispartof><rights>1999 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c316t-ccc849138d6616e6c3e1bf5084ca8668a8d019cb64e0d66e5a74c4ceffb57fdf3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1895943$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/10404806$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>TER MAATEN, J. C</creatorcontrib><creatorcontrib>DE BOER, H</creatorcontrib><creatorcontrib>KAMP, O</creatorcontrib><creatorcontrib>STUURMAN, L</creatorcontrib><creatorcontrib>VAN DER VEEN, E. A</creatorcontrib><title>Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description><![CDATA[Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. Thirty-eight men with childhood-onset GH deficiency were studied for a period of 3-5 yr. Measurements included anthropometry, computed tomographic scanning of abdomen and upper leg, bone densitometry, echo cardiography, and bicycle ergometry. The initial GH dose of 1-3 IU/m2 x day (9-27 microg/kg) was gradually tapered to 1.30+/-0.38 IU/m2 x day (11 g/kg), aiming at physiological insulin-like growth factor I levels. During the study, leg muscle mass progressively increased by 28.7% (P<0.001). Subcutaneous and intraabdominal fat decreased by 30.9% and 46.0%, respectively, after 1 yr (both P<0.001), but demonstrated a partial regain thereafter. Bone mineral density at the lumbar spine, femoral neck, and trochanter gradually increased by 9.6%, 11.1%, and 16.2%, respectively (all P<0.001). Left ventricular mass exceeded baseline values by 14.1% after 1 yr (P<0.001), but returned to pretreatment values thereafter. Stroke volume and cardiac output increased by 16.3% (P = 0.002) and 33.4% (P<0.001), respectively. Maximal work load increased from 189+/-30 to 232+/-41 watts (P<0.001). Thus, long term GH replacement is safe and beneficial. It improves cardiac performance without inducing left ventricular hypertrophy and progressively increases bone mineral density.]]></description><subject>Adult</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure</subject><subject>Body Composition - drug effects</subject><subject>Bone Density - drug effects</subject><subject>Echocardiography</subject><subject>Heart - drug effects</subject><subject>Heart - physiology</subject><subject>Heart Rate</subject><subject>Hormones. Endocrine system</subject><subject>Human Growth Hormone - administration & dosage</subject><subject>Human Growth Hormone - adverse effects</subject><subject>Human Growth Hormone - deficiency</subject><subject>Humans</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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A</creator><general>Endocrine Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19990701</creationdate><title>Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency</title><author>TER MAATEN, J. C ; DE BOER, H ; KAMP, O ; STUURMAN, L ; VAN DER VEEN, E. A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c316t-ccc849138d6616e6c3e1bf5084ca8668a8d019cb64e0d66e5a74c4ceffb57fdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1999</creationdate><topic>Adult</topic><topic>Anthropometry</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure</topic><topic>Body Composition - drug effects</topic><topic>Bone Density - drug effects</topic><topic>Echocardiography</topic><topic>Heart - drug effects</topic><topic>Heart - physiology</topic><topic>Heart Rate</topic><topic>Hormones. Endocrine system</topic><topic>Human Growth Hormone - administration & dosage</topic><topic>Human Growth Hormone - adverse effects</topic><topic>Human Growth Hormone - deficiency</topic><topic>Humans</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Skinfold Thickness</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TER MAATEN, J. C</creatorcontrib><creatorcontrib>DE BOER, H</creatorcontrib><creatorcontrib>KAMP, O</creatorcontrib><creatorcontrib>STUURMAN, L</creatorcontrib><creatorcontrib>VAN DER VEEN, E. A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>TER MAATEN, J. C</au><au>DE BOER, H</au><au>KAMP, O</au><au>STUURMAN, L</au><au>VAN DER VEEN, E. A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>1999-07-01</date><risdate>1999</risdate><volume>84</volume><issue>7</issue><spage>2373</spage><epage>2380</epage><pages>2373-2380</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><coden>JCEMAZ</coden><abstract><![CDATA[Short term GH replacement therapy has been shown to improve body composition and exercise capacity. It is not yet known whether GH replacement remains beneficial over the long term. We assessed the effects of long term GH replacement on body composition, bone mineral density, and cardiac function. Thirty-eight men with childhood-onset GH deficiency were studied for a period of 3-5 yr. Measurements included anthropometry, computed tomographic scanning of abdomen and upper leg, bone densitometry, echo cardiography, and bicycle ergometry. The initial GH dose of 1-3 IU/m2 x day (9-27 microg/kg) was gradually tapered to 1.30+/-0.38 IU/m2 x day (11 g/kg), aiming at physiological insulin-like growth factor I levels. During the study, leg muscle mass progressively increased by 28.7% (P<0.001). Subcutaneous and intraabdominal fat decreased by 30.9% and 46.0%, respectively, after 1 yr (both P<0.001), but demonstrated a partial regain thereafter. Bone mineral density at the lumbar spine, femoral neck, and trochanter gradually increased by 9.6%, 11.1%, and 16.2%, respectively (all P<0.001). Left ventricular mass exceeded baseline values by 14.1% after 1 yr (P<0.001), but returned to pretreatment values thereafter. Stroke volume and cardiac output increased by 16.3% (P = 0.002) and 33.4% (P<0.001), respectively. Maximal work load increased from 189+/-30 to 232+/-41 watts (P<0.001). Thus, long term GH replacement is safe and beneficial. It improves cardiac performance without inducing left ventricular hypertrophy and progressively increases bone mineral density.]]></abstract><cop>Bethesda, MD</cop><pub>Endocrine Society</pub><pmid>10404806</pmid><doi>10.1210/jc.84.7.2373</doi><tpages>8</tpages></addata></record> |
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| ispartof | The journal of clinical endocrinology and metabolism, 1999-07, Vol.84 (7), p.2373-2380 |
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| source | Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list) |
| subjects | Adult Anthropometry Biological and medical sciences Blood Pressure Body Composition - drug effects Bone Density - drug effects Echocardiography Heart - drug effects Heart - physiology Heart Rate Hormones. Endocrine system Human Growth Hormone - administration & dosage Human Growth Hormone - adverse effects Human Growth Hormone - deficiency Humans Insulin-Like Growth Factor I - metabolism Male Medical sciences Pharmacology. Drug treatments Skinfold Thickness Thyroxine - blood Triiodothyronine - blood |
| title | Long-term effects of growth hormone (GH) replacement in men with childhood-onset GH deficiency |
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