Enterochromaffin cells in the stomach of the rat after prolonged administration of cortisol and both cortisol and salmon calcitonin

Young adult male Wistar rats (eight controls and ten experimental animals per group) were injected parenterally for 28 days: 1) cortisol or 2) cortisol and salmon calcitonin. Morphological changes of the stomach wall and enterochromaffin cells, stained immunocytochemically for serotonin, were assess...

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Bibliographic Details
Published in:Journal of endocrinological investigation 1999-05, Vol.22 (5), p.323-326
Main Authors: ORLICZ-SZCZESNA, G, JABTONSKI, M, GORZELAK, M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcitonin - administration & dosage
Calcitonin - pharmacology
Cell Count
Drug toxicity and drugs side effects treatment
Enterochromaffin Cells - chemistry
Enterochromaffin Cells - cytology
Enterochromaffin Cells - drug effects
Epithelial Cells - drug effects
Gastric Mucosa - blood supply
Gastric Mucosa - cytology
Gastric Mucosa - drug effects
Hydrocortisone - administration & dosage
Hydrocortisone - pharmacology
Immunohistochemistry
Male
Medical sciences
Pharmacology. Drug treatments
Rats
Rats, Wistar
Serotonin - analysis
Toxicity: digestive system
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Summary:Young adult male Wistar rats (eight controls and ten experimental animals per group) were injected parenterally for 28 days: 1) cortisol or 2) cortisol and salmon calcitonin. Morphological changes of the stomach wall and enterochromaffin cells, stained immunocytochemically for serotonin, were assessed. In the group treated with cortisol superficial desquamation and erosions of the gastral mucosa were found. In this group the number of enterochromaffin cells was significantly decreased and low intensity of the immunocytochemical reaction of these cells was observed. In the cortisol-calcitonin-treated group there were no apparent changes of the gastral mucosa and the enterochromaffin cells presented a normal picture comparable to that of controls.
ISSN:0391-4097
1720-8386
DOI:10.1007/BF03343568