Genome scan for linkage to Gilles de la Tourette syndrome

Gilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Despite clear evidence for a genetic predisposition to TS from family, twin, and adoption studies, there have been no confirmed linkage findings. In this article we test for linkage to TS i...

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Bibliographic Details
Published in:American journal of medical genetics 1999-08, Vol.88 (4), p.437-445
Main Authors: Barr, Cathy L., Wigg, Karen G., Pakstis, Andrew J., Kurlan, Roger, Pauls, David, Kidd, Kenneth K., Tsui, Lap-Chee, Sandor, Paul
Format: Article
Language:English
Subjects:
Biological and medical sciences
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Genetic Linkage
Genetic Markers
genetics
genome scan
Genotype
Gilles de la Tourette syndrome
Humans
linkage
Lod Score
Male
Medical sciences
Neurology
Pedigree
Tourette Syndrome - genetics
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Summary:Gilles de la Tourette Syndrome (TS) is a neuropsychiatric disorder characterized by both motor and vocal tics. Despite clear evidence for a genetic predisposition to TS from family, twin, and adoption studies, there have been no confirmed linkage findings. In this article we test for linkage to TS in multigenerational families segregating TS using a panel of 386 markers with the largest interval between any two markers being 28 cM and an average distance between markers of 10 cM. We tested for linkage using an autosomal dominant model with reduced penetrance and using nonparametric methods. No significant evidence for linkage was found with parametric analysis. A logarithm of the odds (LOD) score of greater or equal to one under the autosomal dominant model was observed in 24 of these markers in at least one of the families tested. No LOD scores greater than two were observed with any of the markers. For the nonparametric analysis, eight markers were observed with a P‐value less than 0.00005 for significance evidence of linkage in at least one family. However caution should be used in the interpretation of the nonparametric analyses as this statistic (the affected‐pedigree‐member method) is know to have a high false‐positive rate. Further support for linkage in these regions is required before linkage can be assumed. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 88:437–445, 1999. © 1999 Wiley‐Liss, Inc.
ISSN:0148-7299
1096-8628
DOI:10.1002/(SICI)1096-8628(19990820)88:4<437::AID-AJMG24>3.0.CO;2-E