A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury

To investigate whether neuropathic pain is sensitive to spinal GABA levels, GABA was injected intrathecally after nerve injury and sensory behaviors were evaluated. Both thermal and tactile hypersensitivities were permanently reversed at the highest doses of GABA. However, if GABA was injected any l...

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Bibliographic Details
Published in:Brain research 1999-07, Vol.835 (2), p.334-339
Main Authors: Eaton, Mary J., Martinez, Miguel A., Karmally, Shaffiat
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronic constriction injury
Cold Temperature
Cranial nerves. Spinal roots. Peripheral nerves. Autonomic nervous system. Gustation. Olfaction
Dorsal horn
Drug Administration Schedule
Female
gamma-Aminobutyric Acid - therapeutic use
Hyperalgesia - drug therapy
Hyperalgesia - etiology
Inhibitory neurotransmitter
Injections, Spinal
Medical sciences
Nervous system (semeiology, syndromes)
Neuralgia - drug therapy
Neuralgia - etiology
Neurology
Pain
Rats
Rats, Inbred WF
Sciatic Nerve - injuries
Stress, Mechanical
Time Factors
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Summary:To investigate whether neuropathic pain is sensitive to spinal GABA levels, GABA was injected intrathecally after nerve injury and sensory behaviors were evaluated. Both thermal and tactile hypersensitivities were permanently reversed at the highest doses of GABA. However, if GABA was injected any later than 2–3 weeks after nerve injury, it was ineffective to prevent such hypersensitivity. This suggests that altered spinal GABA levels contribute to the induction phase of chronic neuropathic pain and that early intervention to restore GABA may prevent the development of that pain.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(99)01564-4