Differences in human visual evoked potentials during the perception of colour as revealed by a bootstrap method to compare cortical activity. A prospective study

• Published in: Neuroscience letters 1999-07, Vol.270 (1), p.21-24
• Main Authors: Manolas, Manolis G., Stamoulos, Theodore D., Anninos, Photios A.
• Format: Article
• Language: English
• Subjects: Adult; Behavioral psychophysiology; Biological and medical sciences; Bootstrap method; Brain Mapping; Color Perception - physiology; Colour perception; Contrast Sensitivity; Electrophysiology; Evoked Potentials, Visual - physiology; Female; Flicker Fusion; Fundamental and applied biological sciences. Psychology; Heterochromatic flicker photometry; Humans; Male; Models, Statistical; Photic Stimulation; Prospective Studies; Protanopsia; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Visual Cortex - physiology; Visual evoked potentials
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(99)00457-7

The aim of this prospective study was to investigate the colour related information in cortical activity as it is recorded from the scalp, by comparing the shape of the potential fields. Six healthy volunteers and two volunteers with known protanopsia were used to record multichannel visual evoked potentials after stimulation with chromatic stimuli of equally perceived brightness. The scalp fields resulting from each of the four chromatic stimuli were compared in pairs, in every possible combination and for each time point, using Efron's bootstrap method. It was found that, in comparison to other stimuli responses, the long dominant wavelength stimulus results in significant differences of cortical activity. These are mainly identified in two time periods: (a) at mid-latency responses, usually during the onset and development of P100 component, and (b) after the peak (on the decline) of P100 component. Similar but less evident behaviour was identified when the responses from the short dominant wavelength stimulus were compared with those from the other stimuli. Colour effects were not significant in protanops. The proposed method can be used to locate in time and quantify the differences in cortical activity during colour perception.