Serum sialic acid concentration is not associated with the extent or severity of coronary artery disease in patients with stable angina pectoris

Background Total serum sialic acid concentration has been reported to predict death from cardiovascular disease. This study was performed to assess the relation between serum sialic acid concentration and the angiographic extent and severity of coronary atheroma in patients with stable angina. Metho...

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Published in:The American heart journal 1998-10, Vol.136 (4), p.620-623
Main Authors: Salomone, Oscar A., Crook, J.Robert, Hossein-Nia, Mojgan, Holt, David, Kaski, Juan Carlos
Format: Article
Language:English
Subjects:
Aged
Angina Pectoris - blood
Biological and medical sciences
Biomarkers - blood
Cardiology. Vascular system
Coronary Angiography
Coronary Disease - blood
Coronary Disease - pathology
Coronary heart disease
Female
Heart
Humans
Male
Medical sciences
Middle Aged
N-Acetylneuraminic Acid - blood
Severity of Illness Index
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Summary:Background Total serum sialic acid concentration has been reported to predict death from cardiovascular disease. This study was performed to assess the relation between serum sialic acid concentration and the angiographic extent and severity of coronary atheroma in patients with stable angina. Methods Quantitative coronary angiography was performed in 40 patients with stable angina with either triple-vessel disease (23 patients) or normal/nearly normal coronary arteries (17 patients). A colorimetric assay for the enzymatic determination of serum sialic acid was used. Results Serum sialic acid concentration was not significantly different in patients with normal or nearly normal coronary angiograms compared with those with triple-vessel disease (68 ± 10 mg/100 mL and 68 ± 11 mg/100 mL, respectively). Neither was there any association between the extent or severity of coronary disease and serum sialic acid levels. Conclusions Serum sialic acid concentration does not appear to be associated with the extent or severity of coronary artery disease in patients with stable angina pectoris. Thus the previously described association between serum sialic acid and cardiovascular death may reflect the role of mechanisms other than the severity of coronary artery narrowings. (Am Heart J 1998;136:620-3.)
ISSN:0002-8703
1097-6744
DOI:10.1016/S0002-8703(98)70008-0