Chromosomal Localization Reveals Three Kinesin Heavy Chain Genes in Mouse

Kinesin-related proteins constitute a superfamily of microtubule-dependent motors that play important roles in organelle transport and cell division. These molecules share a conserved motor region of approximately 340 amino acids, which is attached to diverse “tail” or cargo-binding domains. The kin...

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Bibliographic Details
Published in:Genomics (San Diego, Calif.) Calif.), 1998-09, Vol.52 (2), p.209-213
Main Authors: Xia, Chun-hong, Rahman, Amena, Yang, Zhaohuai, Goldstein, Lawrence S.B.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Blotting, Northern
Brain - metabolism
Chromosome Mapping
Chromosomes - genetics
Classical genetics, quantitative genetics, hybrids
Eye - chemistry
Fundamental and applied biological sciences. Psychology
Gene Expression
Genetics of eukaryotes. Biological and molecular evolution
Kinesin - genetics
Mice
Molecular Sequence Data
Multigene Family - genetics
Neurons - chemistry
RNA - genetics
RNA - metabolism
Spinal Cord - chemistry
Tissue Distribution
Vertebrata
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Summary:Kinesin-related proteins constitute a superfamily of microtubule-dependent motors that play important roles in organelle transport and cell division. These molecules share a conserved motor region of approximately 340 amino acids, which is attached to diverse “tail” or cargo-binding domains. The kinesin superfamily was first defined by kinesin heavy chain, which is the principal component of “true” kinesin. Invertebrates appear to possess only a single gene encoding kinesin heavy chain. Mammals appear to have two or more genes encoding kinesin heavy chain, although the precise situation has been unclear. Here we definitively demonstrate that mouse has three kinesin heavy chain genes,Kif5a, Kif5b,andKif5c. Kif5a, Kif5b,andKif5cmap to mouse chromosomes 10, 18, and 2;Kif5aandKif5cappear to be expressed only in neuronal tissues by Northern blot analysis whileKif5bappears to be ubiquitous in its expression.
ISSN:0888-7543
1089-8646
DOI:10.1006/geno.1998.5427