No association between dopamine D1, D2, and D3 receptor genes and manic-depressive illness

The dopaminergic receptor genes are candidate genes for manic-depressive illness (MDI). To test this putative involvement we used a case-control study on samples from the native population of the northwest part of France. Fifty patients for D1 and D2, 61 patients for D3, and 86-223 controls were tes...

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Published in:Biological psychiatry (1969) 1998-10, Vol.44 (7), p.644-647
Main Authors: SAVOYE, C, LAURENT, C, AMADEO, S, GHEYSEN, F, LEBOYER, M, LEJEUNE, J, ZARIFIAN, E, MALLET, J
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
Bipolar Disorder - genetics
Bipolar Disorder - psychology
Bipolar disorders
Blotting, Southern
Female
France
Genotype
Humans
Male
Medical sciences
Middle Aged
Mood disorders
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Dopamine D1 - genetics
Receptors, Dopamine D2 - genetics
Receptors, Dopamine D3
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Summary:The dopaminergic receptor genes are candidate genes for manic-depressive illness (MDI). To test this putative involvement we used a case-control study on samples from the native population of the northwest part of France. Fifty patients for D1 and D2, 61 patients for D3, and 86-223 controls were tested. No significant association was found between allelic frequencies or genotype counts and MDI, even when the data were pooled with those from published studies. Single mutations of either of the studied receptor genes are not major determinants of MDI.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(97)00441-1