Rickets in Nigerian children: response to calcium supplementation

In a previous study of rachitic children in Jos, Nigeria we concluded that inadequate dietary intake of calcium was the primary contributing factor to the development of their rickets. The objective of the present study was to determine the effect of calcium supplementation in 10 children with radio...

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Bibliographic Details
Published in:Journal of tropical pediatrics (1980) 1999-08, Vol.45 (4), p.202-207
Main Authors: Thacher, T, Glew, RH, Isichei, C, Lawson, JO, Scariano, JK, Hollis, BW, VanderJagt, DJ
Format: Article
Language:English
Subjects:
Anthropometry
Biological and medical sciences
calcifediol
Calcium, Dietary - metabolism
Calcium, Dietary - therapeutic use
Child
Child, Preschool
Diet
Humans
Infant
Medical sciences
Metabolic diseases
Nigeria
Other nutritional diseases (malnutrition, nutritional and vitamin deficiencies...)
Radiography
Rickets - diagnostic imaging
Rickets - diet therapy
Rickets - metabolism
Statistics, Nonparametric
Tropical medicine
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Summary:In a previous study of rachitic children in Jos, Nigeria we concluded that inadequate dietary intake of calcium was the primary contributing factor to the development of their rickets. The objective of the present study was to determine the effect of calcium supplementation in 10 children with radiographically and biochemically proven rickets from the same geographical area. Rachitic children were provided with calcium supplements of 1000 mg/day for a period of 3 months. Serum and urine samples were obtained at baseline and at 24 hours, 1 week, 4 weeks, and 12 weeks after initiation of supplementation. Serum calcium, phosphorus, alkaline phosphatase, intact parathyroid hormone, 25-hydroxyvitamin D, and 1,25-dihydroxyvitamin D were measured at each time point. Dietary recalls obtained at two separate times were used to estimate usual daily intakes of calcium and phosphorus. Ten non-rachitic age-matched controls from the same geographical area were recruited for comparison. Nine of 10 rachitic subjects had radiographic evidence of healing after 3 months of calcium therapy. Although serum calcium concentrations returned to control levels, other biochemical data indicated that the rickets of these subjects may have been multifactorial in aetiology, pointing to a possible defect in the synthesis of 25-hydroxyvitamin D.
ISSN:0142-6338
1465-3664
DOI:10.1093/tropej/45.4.202